Individuals exposed to pesticides are at increased risk of COVID-19 infection: Research | Weather Channel-Weather Channel Articles

A new study highlights that individuals exposed to organophosphorus pesticides may be at increased risk of COVID-19 infection.

The study, led by Saurabh Chatterjee and a team at the University of South Carolina in the United States, identified the underlying mechanisms associated with inflammation that may increase the susceptibility of people exposed to organic phosphate to COVID-19 infection. It was. This study was performed on human lung airway cells.

In addition, the findings also show that people with type 2 diabetes and cancer tend to show the same type of inflammation, which may increase their risk of coronavirus.

Exposure to organophosphorus pesticides causes Gulf War disease. This is a collection of medically unexplained chronic symptoms such as malaise, headache, arthralgia, dyspepsia, insomnia, dizziness, respiratory illness, and memory loss.

The team investigated whether exposure to the organophosphorus pesticide chlorpyrifos and elevated levels of interleukin 6 (IL-6) could increase the risk of SARS-CoV-2 infection.

They exposed human lung airway epithelial cells in combination with IL-6 and / or chlorpyrifos for 6 hours. Another group of cells was not exposed to function as a control.

The researchers then treated the cells with a peplomer that linings SARS-CoV-2. During infection, the peplomer binds to the angiotensin converting enzyme 2 (ACE2) receptor and binds to cells, triggering the process by which the virus can release its genetic material into healthy cells.

They found that cells exposed to IL-6 and pesticides exhibited increased or controlled cell death in the presence of SARS-CoV-2 peplomer.

Cells exposed to both pesticides and IL-6 showed significantly higher ACE2 expression on the apical cell surface compared to cells not or exposed to pesticides alone. The apical membrane of airway cells faces the interior of the airway, and the basolateral membrane is in contact with surrounding tissue. Researchers explained that increased expression of ACE2 receptors on the apical surface meant that more virus would attach to cells.

“People with obesity, type 2 diabetes, or cancer also have high circulating IL-6 levels, which increases the translocation of ACE2 receptors to apical cells, so people with these conditions are also susceptible to SARS-CoV-2 infection. Is expected to increase. The surface. “

The findings will be presented at the Virtual Experimental Biology (EB) 2021 conference, which will be held April 27-30.

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