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Hepatitis C drug shown to increase the activity of remdesivir against SARS-CoV-2

Hepatitis C drug shown to increase the activity of remdesivir against SARS-CoV-2

 


The four hepatitis C drugs have proven promising as boosters that increase the efficacy of remdesivir against SARS-CoV-2 by a factor of 10.

SARS-CoV-2 treatment


Researchers have shown that four drugs used to treat hepatitis C can improve remdesivir inhibition by a factor of 10. SARS-CoV-2 In cell culture. The study was conducted at the University of Texas at Austin, Rensselaer Polytechnic Institute (RPI), and Mount Sinai School of Medicine in the United States.

According to the team, these results indicate that a mixture containing remdesivir and a recycled hepatitis C virus (HCV) drug may function as a combination antiviral therapy with SARS-CoV-2. .. Such antivirals may provide immediate treatment to infected, unvaccinated or immunized vaccinated people.

Such combination therapies are not recommended because these hepatitis drugs have already been approved for use and their potential side effects are known. New drug..

“Our goal is to develop a combination of oral medications that can be given to outpatients before they become ill enough to require hospitalization,” said Professor Robert Krug, co-author of a paper at the University of Texas at Austin. Says. “HCV drugs that increase the antiviral activity of remdesivir are oral drugs. Ideally, to develop an effective combination therapy, an oral drug that inhibits SARS-CoV-2 in the same way as remdesivir is needed. . “

The team explains that remdesivir targets a portion of SARS-CoV-2 called RNA polymerase, allowing the virus to replicate. HCV drugs, on the other hand, target two other parts of HCV, called proteases, which are also important for viral replication.

This study was motivated by the discovery that there was a significant similarity between the structure of the HCV protease and one of the SARS-CoV-2 proteases called the main protease (M).Professional). They suspected that existing drugs that bind and inhibit HCV protease may also bind and inhibit this SARS-CoV-2 protease.

The team used a supercomputer to model how the drug binds to viral proteins and predicted that 10 HCV drugs would bind exactly to the SARS-CoV-2 protease. Researchers tested seven of these drugs in a safe biocontainment facility for their ability to inhibit SARS-CoV-2 virus replication in culture-growing monkey and human cells.

All seven HCV drugs inhibited virus replication, but the team found that four of them (simeprevir, vaniprevir, paritaprevir, and glazoprevir) inhibit a completely different type of SARS-CoV-2 protease called papain-like protease. discovered. When each of the seven HCV drugs was tested for virus inhibition in combination with remdesivir, only four that targeted unexpected proteases increased the efficacy of remdesivir by a factor of 10.

The study was published in Cell report..

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