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Research has discovered a new and highly effective treatment for vitamin D deficiency

Research has discovered a new and highly effective treatment for vitamin D deficiency

 


New studies show that 25-hydroxyvitamin D3 is an effective treatment for vitamin D deficiency in certain patients.

There are millions of people around the world suffering from a variety of malabsorption syndromes, including those who have undergone gastric bypass surgery and those who are obese. These patients often have difficulty absorbing vitamin D, and both groups of patients are at increased risk of vitamin D deficiency and therefore osteoporosis and osteomalacia (bone softening).

Obese patients are also more susceptible to vitamin D deficiency because vitamin D, which results from intestinal absorption and skin synthesis, is diluted in a larger body pool of fat. The results of these findings are published online in the American Journal of Clinical Nutrition.

According to researchers, about one-third of adults are obese and require much higher amounts of vitamin D to meet their requirements. “This vitamin D metabolite is well absorbed by patients with malabsorption syndrome and is not fat-soluble, so it is not diluted with body fat and maintains elevated blood levels of 25-hydroxyvitamin D in obese people. “It’s effective,” explained its corresponding author, Michael F. Holick, PhD, MD, a professor of medicine, physiology, biophysics, and molecular medicine at the University of Boston School of Medicine.

A more water-soluble form of vitamin D3, known as 25-hydroxyvitamin D3, has a higher vitamin D status than the same dose of vitamin D3, comparing healthy adults, adults with malabsorption syndrome, and obese adults. We evaluated whether it was effective in improving. Researchers found that only about 36% of orally ingested vitamin D3 was detected in the blood of patients with malabsorption syndrome, including those who underwent gastric bypass surgery, compared to healthy adults. I observed.

When the same adult took 25-hydroxyvitamin D3, patients with malabsorption syndrome were able to absorb it as well as healthy adults, thereby raising vitamin D status to the same extent. Similar observations were made in obese subjects compared to healthy controls. “Therefore, the use of 25-hydroxyvitamin D3 may be a new approach to treating vitamin D deficiency in patients with malabsorption syndrome and obese adults,” Holick added.

Vitamin D deficiency not only results in bone loss, which increases the risk of fractures, but also causes osteomalacia, a painful bone disease. Patients with vitamin D deficiency with osteomalacia have relentless pain in their bones and muscles. Vitamin D deficiency is associated with an increased risk of many chronic illnesses, including multiple sclerosis, type 1 diabetes, heart disease, type 2 diabetes, depression, neurocognitive dysfunction, Alzheimer’s disease, and Covid. doing.

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