Patients with Hematological Cancer Can Fight COVID-19 Infection by T Cells: Research | Weather Channel-Weather Channel Articles

Antibodies are not the only immune cells needed to fight COVID-19. T cells, which can step up to work when antibodies are depleted, have also been found to be equally important, suggesting a new study of coronavirus hematological cancer patients. The results of this study are Nature medicine journal.

Researchers at the University of Pennsylvania have found that patients with COVID-19 blood cancer who are high in CD8 T cells and depleted of antibodies in cancer treatment are more than three times more likely to survive than patients with low CD8T levels. did. cell.

“It is clear that T cells are important in terms of early infection and help control the virus, but they can supplement B cells and antibody responses that hematological cancer patients are likely to miss because of the drug. We also showed, “said Alexander. C. Huang, Associate Professor of Hematology Oncology, Perelman School of Medicine, Varsity.

“This is important when considering ways to improve the care of cancer patients with COVID. Maximize all arms of the immune system, especially if you know that certain arms of the immune system are down. “We need to do that,” Huang added.

In addition, current COVID-19 mRNA vaccination induces both antibody and T cell responses, so the findings show that vaccination of hematological cancer patients protects T cell immunity in the absence of antibodies. It suggests that you can do it.

The team found that patients with blood cancer were more likely to die of COVID-19 than patients with or without solid tumors.

In addition, by immunoprofiling blood samples from 214 patients, patients with blood cancer, especially those treated with anti-CD20 antibody, had B cells and compared to patients with solid cancer and those without cancer. It became clear that the antibody was reduced.

Additional analysis shows that among patients with hematological cancer, including those treated with chemotherapy or anti-CD20 antibody, patients with high CD8 T cell counts are 3.6 times more likely to survive than those with low numbers. It also became clear that it was expensive.

Therefore, the researchers concluded that CD8 T cells may affect recovery from COVID-19 if B cells and antibodies are deficient.

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