Health
Covid-19 acquires new mutations to escape immune response
Researchers in India and the United States claim in a new study that the new coronavirus (SARS-CoV-2) has acquired a new genetic mutation that can evade immune response and mass vaccination. Viruses dominate over humans.
During the second surge from February 2021 (1.1%) to April 2021 (15%), India saw a 10-fold increase in such mutations. Found.
When asked if existing vaccines would work against viruses with such mutations, one of the team leaders, Venky Soundararajan, told DH: This is an ongoing promotion of research with collaborators in the United States, EU and India. “
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The study, conducted by scientists at nference, a U.S.-based medical technology company, in collaboration with medical researchers at the Mayo Clinic, is a “breakthrough infection” that is not protected by vaccination against the new coronavirus infection. It may also provide an explanation for “symptoms”. Two doses of vaccine.
Despite state reports of such cases, the Ministry of Health, Labor and Welfare has not released estimates of such groundbreaking infections. Recent evidence from the United States shows that approximately 0.01% of the fully vaccinated population has a breakthrough infection rate.
According to scientists, the main contribution of the new study is to show how SARS-CoV-2 acquires strategic mutations to avoid herd immunity acquired by mass vaccination.
Such mutations, in which the virus sheds small fragments of the genome under the pressure of natural evolution and makes it difficult for antibodies to survive, are seen in spikes, which means increased human-to-human transmission.
“We have identified that deletion mutations in peplomers are likely to be associated with a surge in outbreaks, and are new in the SARS-CoV-2 Indian subspecies and the recent surge in SARS-CoV. A surge-related deletion mutation was identified. -2 variants were found in Chile, “said Soundararajan, co-founder and chief scientific officer of nference.
This study provides a new explanation linking the prevalence of viral genomic mutations to test-positive rates across all countries and periods, and provides a genomic compass to identify emergency variants of concern at the earliest signal. I will.
“We also identified a distinct set of deletion mutations among patients infected with SARS-CoV-2 after reinfection or vaccination. Overall, regions prone to deletion of the Spike protein continue to occur. It shows evolution and expansion. Newly emerging deletion mutations, “he added.
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