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Cleveland Clinic Researchers Identify Linkage of COVID-19 to Brain Disorders Like Alzheimer’s Disease

 


Neurological problems are common, but Symptomatology Little is known about this underlying mechanism among COVID-19 long-haul carriers. A new study led by researchers at the Cleveland Clinic may give a glimpse of the answer.

Study published on June 9 Research and treatment of Alzheimer’s diseaseLeveraging artificial intelligence, we compared existing datasets between patients with COVID-19 and patients with Alzheimer’s disease.

Researchers found no evidence that the virus infects the brain directly, but is based on a close network of SARS-CoV-2 and genes / proteins associated with Alzheimer’s disease and several other neurological disorders. They then evaluated the potential association between COVID-19 and the two hallmarks of Alzheimer’s disease, neurological inflammation and cerebral microvascular injury.

“We have found that SARS-CoV-2 infection significantly alters Alzheimer’s disease markers involved in Brian’s inflammation and that certain viral entry factors are highly expressed in cells of the blood-brain barrier.” Said Dr. Feixiong Cheng, lead author of the study and assistant staff at the Institute of Genomic Medicine at the Cleveland Clinic. “These findings indicate that the virus affects several genes or pathways involved in neuroinflammation and brain microvascular injury, which can lead to cognitive deficits such as Alzheimer’s disease.”

Dr. Chen and his team are currently conducting research aimed at identifying measurable biomarkers and potential new therapeutic targets for COVID-19-related neurological problems.

“Identifying how COVID-19 is associated with neurological problems provides an effective preventive and therapeutic strategy for coping with the anticipated surge in neurocognitive impairment in the future. It’s important for development, “said Dr. Chen.

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