Role of Mutant p53 in Enhanced Atherosclerosis

There is new evidence that there are mutations in p53 Contributes to the development of atherosclerotic cardiovascular disease.

Valentin Fuster, president of Mount Sinai Heart and Chief Physician of Mount Sinai Hospital, said these findings “explain how acquired mutations in blood cells, a phenomenon called clonal hematopoiesis, act as cardiovascular risk factors.” It expands our knowledge of what to do,” he said. , and author of the report.

new studywas published in Nature cardiovascular researchThe project was carried out by a team from Spain’s National Cardiovascular Research Center (CNIC) in collaboration with several US laboratories.

It has long been known that age-related clonal hematopoiesis is a common condition and is in part associated with an increased risk of hematological cancers and increased all-cause mortality. probably Because it increases the risk of cardiovascular disease.

Every day, adults generate hundreds of thousands of blood cells, leading to mutations in progenitor cells. increase the risk ofThe role of p53 in cancer is well known Studied.

Working with groups led by Derek Klarin of Stanford University, Pradeep Natarajan of Massachusetts General Hospital, and Alexander Bick of Vanderbilt University, these scientists analyzed sequencing data from more than 50,000 blood cells.

“Carriers of acquired mutations in p53 are at increased risk of developing coronary heart disease and peripheral artery disease, and this effect is in contrast to established cardiovascular risk factors such as hypertension and elevated blood cholesterol. It turned out to be irrelevant,” explained José Javier Fuster.

Scientists next performed functional studies in an animal model of atherosclerosis into which the cells were introduced. p53 mutation.

They found that mice with these mutations developed cardiovascular disease more rapidly. This is primarily due to an abnormally increased proliferation rate of immune cells in the arterial walls. This study shows that p53 mutations are the underlying cause of most cardiovascular diseases and also promote the development of atherosclerosis, a leading cause of death worldwide.

“Combining observations in humans with studies in animals provides robust evidence that these mutations increase the risk of developing cardiovascular disease,” said José Javier Fuster.

A previous study by the same group had already demonstrated it in 2021. article of Journal of the American College of Cardiology (JACC) says that some of these mutations, such as those affecting the TET2 gene, contribute to the development of cardiovascular disorders such as atherosclerosis and heart failure.

“In addition to validating that previous study, our new results now highlight our findings to include mutations in p53 and the development of peripheral arterial disease, a condition that is particularly common in the elderly population.” We are extending our findings,” said José Javier Fuster.

Researchers emphasize that mutations in different genes contribute to cardiovascular disease through different mechanisms. “In the future, this could be used to design individualized prevention strategies targeted at the specific effects of different mutations,” said one of the study’s co-authors. Her CNIC scientist Nuria Matesanz said.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos