BCG vaccine increased risk of severe COVID-19 in certain populations

According to the authors of a recent study published in , the Bacillus Calmette-Guerin (BCG) vaccine did not reduce the risk of COVID-19 infection among healthcare workers less than placebo. New England Journal of Medicine (NEJM). Patients who received the BCG vaccine had a 7.6% risk of severe COVID-19 infection at 6 months, compared with a 6.5% risk for placebo.

Lee Prazer – stock.adobe.com

“Although confidence intervals were wide and there was no difference between the two groups, the probability of a COVID-19 episode within six months was higher in the BCG group than in the placebo group,” the study authors wrote. There is NEJM article.

Originally, BCG was created for tuberculosis. However, severe he has immunomodulatory ‘off-target’ effects that may protect against other infections such as COVID-19. It was thought that CBG as a pathogen-specific vaccine could enhance her protection against COVID-19.

BCG Danish vaccine (equivalent to 2-8 x 105 colony forming units) [CFUs] Danish strain 1331 of Mycobacterium bovis. AJ Vaccines) reduced the incidence and severity of his COVID-19 in adult patients more than placebo. The primary outcome was symptomatic COVID-19 and his severe COVID-19 assessed at 6 months. Secondary outcomes included time to onset of COVID-19, number of COVID-19 episodes, number of days with onset, days off work, and complications.

The investigative team randomized a modified intention-to-treat population of 3988 participants in the international, double-blind, placebo-controlled, and multistage clinical trial BRACE study. received the intradermal BCG Danish vaccine and 1683 received a saline placebo. The participant was assessed for primary outcomes at his 6 months during the 12-month follow-up.

The data showed an adjusted estimated risk of developing symptomatic COVID-19 of 14.7% in the BCG group and 12.3% in the placebo group. Most of his 7.6% and his 6.5% of participants with severe COVID-19 infection were not hospitalized (he was on BCG and placebo, respectively), and researchers observed no new safety concerns. I did.

The BCG group was more likely to have a COVID-19 episode within the 6-month evaluation period. However, while BCG was associated with a reduction in symptom days in adults aged 60 years or older, there was no significant difference between symptom days in participants aged 40 to 59 years or in participants younger than 40 years. There was no.

Additionally, BCG patients with pre-existing conditions were likely to experience more symptoms than the placebo group. They also likely had severe or symptomatic her COVID-19, so “the results did not rule out a possible increased risk,” the study’s authors wrote in the article.

The study authors noted that study limitations included an inability to employ the planned sample size and reduced observation time, making the study error prone. The study authors also noted that the definitions of “severe” and “syndromic” for COVID-19 are limited and may differ from traditional definitions. Additionally, the study included blinding.

“It is important that our findings are not extrapolated beyond the effects of the BCG-Denmark vaccine against COVID-19 in healthcare workers,” the study authors wrote. We demonstrate beneficial off-target effects of the BCG vaccine in the setting of

reference

Pittet L, Messina N, Orsini F, et al. A randomized trial of the BCG vaccine to protect healthcare workers from Covid-19. N Engl J Med2023. doi:10.1056/NEJ Moa2212616

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos