Health
Sotrobimab shows promising results in the fight against the virus
United Arab Emirates, where Delta is widespread and logistics are military grade, Announcing impressive resultsThere were no deaths among the 6175 COVID-19 patients treated in July.
Nonetheless, and decisively, immunologists are worried that indiscriminate use of a single antibody, such as sotrobimab, could lead to the emergence of resistant mutants that could leak to the community. It is not a substitute for vaccination. The ethical issues are clear.
Monoclonal antibodies attack and nullify unwanted targets. Consider Herceptin for breast cancer, Keytruda for melanoma, Emagality for migraine, and Humira for arthritis. All monoclonal antibodies have been created or modified for very specific targets. Each is a feat of structural molecular engineering.
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It was Sir Gregory Winter, a scientist in Cambridge, England, who devised and developed the general technology behind monoclonal antibodies. Initially, companies didn’t realize the potential. And as he said at the 2018 Nobel Prize speech and the University of Sydney in 2019, It was a seed fund from the Australian racing industry We launched a monoclonal antibody on the market. The transaction took place on a boat in Sydney Harbor. He heard a whispering comment.Give Greg money.Let’s see how Boffin trot“. Today, the annual revenue of monoclonals is well over $ 100 billion, and the human benefits are immeasurable.
Australia’s point of view has come to an end. Professor Daniel Christ is a former PhD student in Winters and is currently at the Garvan Institute. He is looking at ways to avoid this antibody resistance problem. And he looks to the experience of treating HIV infection with three different drugs that controlled the epidemic.
Since the beginning of 2020, his team has been working hard to develop monoclonal antibodies against COVID-19. They currently have three antibodies that are more potent than sotrobimab in vitro. When used together, it should be very resistant to mutation avoidance.
If these ventures are successful, Australians have good reason to appreciate their investment in science.
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