NHS, Vertex Strike Deal, Kaftrio Now Available in UK

NHS England And Vertex Pharmaceuticals Agreement reached to allow access to Vertex Kaftrio (ivacaftor/ tezacaftor / elexacaftor), for triple combination therapy Cystic fibrosis Used in combination regimen with (CF) Calideco, As soon as the drug is approved European Commission..

This agreement redeems access to Kaftrio (sold as Trikafta in the US) if approved in Europe. Previous redemption contract Vertex’s other approved CF drugs, ie Calideco (Ivacaftor), Orcambi (Luma Kahutor/ ivacaftor) and Shimkebi (Tezacaftor / ivacaftor combo). The agreement also covers future indications for these drugs.

“We are pleased that NHS England recognizes the value of Kaftrio and allows Vertex and NHS England to work quickly, collaboratively and flexibly. Include triple therapy prior to approved drugs We are expanding our existing reimbursement agreement,” said Dr. Reshma Kewalramani, President and CEO of Vertex. Press release..

“This will allow eligible patients in England to benefit from access to this innovative drug, which was first approved in Europe,” Kewaramani said.

of Human Drug Committee (CHMP), part of European Medicines Agency,Recently Announced a positive opinion About the use of Kaftrio in combination with Kalydeco as a treatment for CF over the age of 12 with two F508del mutations (the most common CF-causing mutations) or one F508del mutation and one minimal function mutation CFTR gene (Gene with defective CF).

This opinion result AURORA clinical trial (NCT03525444 And NCT03525548), which showed that Kaftrio significantly reduced exacerbations and improved lung function in CF patients with one or two F508del mutations

The new contract covers access to Kaftrio for English CF patients with two F508del mutations, or one F508del mutation and one minimal function mutation.

“The signing of the deal between NHS England and Vertex Pharmaceuticals is great news and Kaftrio will be available to thousands of people across England over the next few weeks. This really saves lives. Will be,” said British CEO David Ramsden. Cystic fibrosis trustSaid in Press release..

in addition, By agreement Kaftrio and other Vertex drugs are prescribed to individuals with rare mutations, US Food and Drug Administration (FDA).

“We also have the flexibility to allow clinicians to use not only European licenses and other future indications, but also other drugs in their portfolio for rare mutations that may be covered by US FDA licenses. Simon Stevens, CEO of NHS, Health and Social Welfare Selection Committee According to the Trust press release, the conference.

“This is a very important day for people with cystic fibrosis and we really address the underlying cause of the disease by helping the lungs function effectively,” Stevens said.

The agreement may also pave the way for similar agreements in Scotland, Northern Ireland and Wales.

Alexandra Andrews, a 45-year-old CF patient from Nottingham, England who has been taking Kaftrio for compassionate reasons since May 2020, said: It has improved my endless life. I can actually do many of the little things in life. I can exercise again and I feel healthy. This medicine made a huge difference and helped me to feel better. Now you can talk without being out of breath. It’s like a miracle drug that gave me a new life lease. “

Science writer Marisa holds a master’s degree in cellular and molecular pathology from the University of Pittsburgh to study new genetic factors in ovarian cancer. She specializes in cancer biology, immunology and genetics. Marisa started a partnership with BioNews in 2018 and writes about Science and Health for SelfHacked and the American Genetics Society. She also composes/composes musicals and teaches the Fencing Club at the University of Pittsburgh.

Total posts: 336

Patrícia holds a PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She studied applied biology at Unihosidade do Minho and was a postdoctoral researcher at the Instituto de Medicina Molecular in Lisbon, Portugal. Her research focuses on the molecular genetic traits of infectious agents such as viruses and parasites.

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