Changing how monkeypox vaccine is injected could mean higher doses, but it may not be easy, experts say

As part of the Biden administration’s declaration of the monkeypox outbreak in the United States as a public health emergency, it is considering administering the Jynneos vaccine intradermally rather than subcutaneously.

“We are considering an approach to Jynneos’ current dosage that would allow providers to use existing single-dose vials of the vaccine to administer up to five separate doses,” Califf said.

Monkeypox vaccine is currently given subcutaneously. That is, it is delivered under the skin. But with intradermal vaccination, “basically, it stays in the skin. It doesn’t go through the skin,” says Daniel Griffin, M.D., an infectious disease expert at Columbia University.

Influenza and rabies vaccines use smaller intradermal injections, epidemiologist Dr. Jay Varma told CNN in an email.

“The skin has special cells that are very good at helping vaccines stimulate the body’s immune system,” he writes.

These cells, called dendritic cells, are highly capable of generating an immune response, Griffin said.

“They live in the skin and are good at teaching the immune system what it needs to respond to,” he said.

“If we can administer the monkeypox vaccine intradermally, we can lower the dose. We just need to prove that we get the same immune response,” he said.

The administration of this vaccine still needs to be studied, Griffin said, but because monkeypox vaccine research and approval is based on antibody responses, not necessarily on efficacy, data on whether it works will be available soon. increase.

Can a doctor give these injections?

While this method can help expand the limited supply of Jynneos, it can also come with challenges.

“It’s a great idea,” Griffin said, given the high demand for the vaccine. I think it’s a great idea on how to make the amount you have much bigger.”

Dr. William Schaffner, professor of infectious diseases at Vanderbilt University, says these types of injections can be difficult to perform.

“There are challenges with delivering intradermal vaccination. It sounds good, we can deliver more vaccine, but we have to do it right,” he said. There are nurses out there who know how to do this, but the average nurse needs some practice before actually doing this.I don’t trust doctors to do it. They never did it..”

Tuberculosis skin tests use intradermal injections.

“I would like to reach out and reuse a lot of TB nurses because there are so many nurses doing old TB skin tests,” Schaffner said. “They know how to do this and I would expect them to actually administer the vaccine.”

Caliph said “nothing has changed” in the injection method.

“I’m confident about the dosage because it’s routinely done in other situations,” he said.

Dawn O’Connell, assistant secretary for preparedness and response at the U.S. Department of Health and Human Services, said Thursday that 150,000 doses of the Gynneos vaccine are expected to arrive in the U.S. Strategic National Stockpile in September – previously scheduled. The arrival was earlier than the month of October. O’Connell also said that so far he has sent 602,000 cans of his Jynneos to states and jurisdictions.

The US Centers for Disease Control and Prevention estimates that at least 1.5 million people in the United States are eligible for monkeypox vaccination.

CNN’s MJ Lee contributed to this report.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos