Health
Common red food coloring causes intestinal inflammation, colitis
- A recent study investigated the effect of the commonly used food dye “Allura Red” on intestinal inflammation and whether it could lead to inflammatory bowel disease (IBD) and colitis. did.
- Using animal models, they found that chronic but not intermittent consumption of Allura Red induced mild intestinal inflammation in mice.
- Researchers hope their findings will bring consumer attention Potential harm of food coloring.
Inflammatory Bowel Disease (IBD) It is characterized by chronic inflammation of the gastrointestinal tract.
In 2017,
gain
Valuable research shows that food additives titanium dioxideused to give food an opaque white color, gut microbiota and intestinal function.
Further research into how food additives affect gut health may improve public awareness and health policy regarding food consumption.
In a recent study, researchers evaluated the effects of the red food dye Allura Red (AR).
This study found that mice exposed to AR during childhood were more susceptible inflammation, a chronic disease characterized by inflammation of the lining of the colon. The findings also showed that chronic exposure to AR induced mild colitis.
The survey results are
Western food Contains high levels of additives, fat, red meat and sugar low intake fiber is known to cause chronic intestinal inflammation.
Food additives, emulsifiers and synthetic colorants are widely used to improve the texture, shelf life and aesthetics of food.
Allura red is commonly found processed food Candies, snack foods, soft drinks, dairy products, cereals, etc.:
- skittles
- strawberry fanta
- Doritos Nacho Cheese Tortilla Chips
- fruit loop
- Nabisco Oreo Winter Chocolate Sand Cookie
For this study, researchers examined the effects of several common food colors on serotonin production.
- AR
- Brilliant Blue FCF
- Sunset Yellow FCF
- tartrazine yellow
All coloring agents stimulated serotonin secretion, but AR was found to have the most pronounced effect. So they further investigated AR in mice fed different diets for 12 weeks.
- standard diet
- Daily AR-inspired meals
- AR Infusion Diet 1 day a week
AR intake was calculated according to the acceptable daily intake level for humans. Colitis was induced by chemical exposure 7 days after his diet.
They found that intermittent exposure to AR (most similar to human exposure) did not increase susceptibility to colitis.
However, mice that received AR daily He developed mild colitis and was associated with elevated serotonin levels and poor intestinal nutrient absorption.
From other experiments, researchers found that similar effects occur when AR is consumed with food or water.
They also investigated the effects of AR exposure in young mice. They fed a 4-week-old mouse with standard chow or AR for his 4 weeks.
They found that early exposure to AR induced mild colonic inflammation and altered the expression of genes associated with antimicrobial responses.
Further testing showed that AR did not increase susceptibility to colitis in mice lacking tryptophan hydroxylase 1 (TPH1), an enzyme used to synthesize serotonin in the gut.
They pointed out that this means that AR affects the gut microbiota via the serotonergic system.
Dr. David Fudmanan assistant professor of medicine in the Division of Gastroenterology and Liver Diseases at the University of Texas Southwestern Medical Center, who was not involved in the research. medical news today Regarding study limitations:
“The main limitation of these findings is that they were generated in a mouse model of colitis, in which exposure to chemicals causes colitis. We do not know if the same is seen in humans with colitis. For this reason, caution should be exercised in interpreting animal study data.”
Still, Dr. Fudman noted that animal studies are important for determining areas for further research in humans so that the results can be used in medicine and teaching.
Principal study author Wariul KhanPhD, professor of pathology and molecular medicine at McMaster University in Hamilton, Ontario, Canada. news release:
“Our findings are surprising and alarming because this common synthetic food dye can cause IBD. It is an important advance in warning the public about the potential harm of
Dr. Khan also pointed out that the literature suggests there may be other health effects from consuming allura red.
Allura Red may affect certain allergies, immune disorders, and behavioral problems in children, including: Attention deficit/hyperactivity disorder (ADHD)continued Dr. Khan.
Dr. Fudman added that there is growing evidence that dietary exposure is involved in the development of IBD.
“This data should drive further investigation as to whether this food additive may play a role in the development of IBD in humans,” Dr. Fudman concluded.
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