Discovered a new part of the brain’s waste disposal system

Along Claire Wilson

A new anatomical structure has been discovered that is part of the brain’s waste disposal system.

This tissue is a thin membrane that envelops the brain and separates the newly-made cerebrospinal fluid that circulates in the brain from the “dirty” fluid that contains cellular waste products.

It was already known that there are three membranes between the skull and the brain. The new structure is her fourth membrane above the innermost membrane called the subarachnoid lymphoid membrane (SLYM). It is very thin, only a few cells wide, sometimes even a cell.

SLYM says one reason, previously unnoticed, is that the membrane collapsed when the brain was removed from the skull after death. Miken Nedergaard Helped find the structure at the University of Rochester Medical Center in New York. It’s also too faint to be seen by a living person via a brain scanning device.

The tissue was first discovered in mice after Nedergaard’s team used a genetic tagging technique that caused SLYM’s cells to glow fluorescent green. Later, it was also observed to cover human brains by melting the skulls of corpses donated for research.

In 2012, Nedergaard also helped discover a network of thin tubes that collect waste fluid from brain cells. glyphatic systemThese tubes can drain into the outflowing cerebrospinal fluid, says Nedergaard.

Brain cell waste products include beta-amyloid and a protein called tau. implicated in Alzheimer’s disease when they accumulate in excess.

In both mice and humans, SLYMs also contain immune cells, Nedergaard said, which could potentially detect signs of infection present in the cerebrospinal fluid. “It’s filled with immune cells.”

“This is a fascinating finding with important implications for our understanding of the glymphatic system,” he said. political commentary at the University of Exeter, UK.

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