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Lab-grown eye cells can treat blindness

Lab-grown eye cells can treat blindness

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Recent W-News article He described the latest efforts to treat blindness in humans. More than a decade ago, scientists at UW Madison devised a method to grow organoids that resemble the retina. They reprogrammed human skin cells to develop cells that can sense light and transmit data to the brain. However, it is not yet known whether these laboratory-cultured cells will function properly after being disassembled, which would be essential for transplantation into a patient’s eye.

Cells in the retina and brain communicate via synapses, and to prove that lab-grown retinal cells can replace diseased cells, they must also make synapses. Studies have shown that photoreceptors grown in the lab respond to different wavelengths and light intensities, just like photoreceptors in healthy retinas, and can even reach their neighbors via axons. rice field. A team from the University of Madison has shown that lab-grown organoids can be broken down into individual cells and spread rabies connections to develop synaptic connections. They found that the most common retinal cell types that form synapses are photoreceptors (rods and cones), which are lost in disease and eye damage.

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