Health
Relationship between periodontal disease-related bacteria and colorectal cancer
At a glance
- Scientists have identified a specific subtype of bacteria involved in periodontal disease that may promote the growth of colorectal tumors.
- The results suggest that treatments targeting these bacteria within tumors may help reduce the severity of some colorectal cancers.
Colorectal cancer (cancer of the colon and rectum) is the fourth most common cancer in the nation. The incidence of colorectal cancer among young adults is increasing, although overall incidence rates are steadily decreasing due to improved screening techniques. Researchers have been working hard to figure out the cause.
Bacteria involved in periodontal disease, Fusobacterium nucleatumhas also been found in some colorectal cancer tumors. F. nucleatum It is rarely found in the intestines of healthy people. Colorectal tumors harboring these bacteria are associated with more cancer recurrence and worse patient outcomes than tumors without these bacteria. However, it is unclear how much of a role bacteria play in causing tumor growth.
F. nucleatum They are normally present at low levels in the oral cavity, but they can multiply and, along with other microorganisms, cause inflammation and cause gum and periodontal disease. Over time, this inflammation can lead to destruction of the bone and tissue that supports the tooth, resulting in tooth loss. Years of research have linked periodontal disease to other conditions throughout the body, such as heart, kidney, autoimmune diseases, and even some cancers. However, in most cases, scientists still do not fully understand the extent to which periodontal disease contributes to the cause of these symptoms.
Led by a research team funded by the NIH. Martha Zepeda Rivera, Susan Bulman, and Christopher D. Johnston of the Fred Hutchinson Cancer Center made a careful genetic comparison between the two. F. nucleatum one from a colorectal tumor and one from a healthy mouth.They analyzed the genomes of 80 people F. nucleatum Strains from the mouths of people without cancer and 55 strains from tumors of colorectal cancer patients. The results of this study were published on March 20, 2024. Nature.
The research team discovered that the following variants exist: F. nucleatumcalled Crucian carp, were more likely to be present in colorectal tumors. Further analysis revealed that there are two distinct types. Crucian carp. Both were present in her mouth, but only one type was called hers. Crucian carp C2 was associated with colorectal cancer.
When researchers infected mice with intestinal inflammation (an animal model for colitis) with these two viruses, they found that F. nucleatumfound that mice were infected. Crucian carp C2 developed more tumors than those infected with other types.
How these bacteria travel from the mouth to the colon is still poorly understood. However, researchers showed that: Crucian carp C2 can survive longer than other types of C2 under acidic conditions, such as those found in the intestines. Crucian carp. This suggests that bacteria may travel along a direct route through the gastrointestinal tract.
“We have identified the precise bacterial lineage associated with colorectal cancer, and that knowledge is essential for developing effective prevention and treatment strategies,” says Dr. Johnston.
Future research could test whether specifically targeting F. nucleatum In colorectal tumors, patient outcomes can be improved.Clinicians may also be able to screen someday Crucian carp C2 identifies colorectal tumors that are likely to be aggressive.
—Written by Dr. Vanessa McMains
References: A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche. Zepeda-Rivera M, Minot SS, Buzek H, Wu H, Blanco-Migüez A, Mangi P, Jones DS, Lacourse KD, Wu Y, McMahon EF, Park SN, Lim YK, Kempczinski AG, Willis AD, Cotton SL. , Yost[ PubMed ][ 相互参照 ]Sicinska SC, Sicinska E, Kook JK, Dewhirst FE, Segata N, Bullman S, Johnston CD. Nature. March 20, 2024. doi: 10.1038/s41586-024-07182-w. Online ahead of print. PMID: 38509359.
Funding: NIH's National Cancer Institute (NCI), National Institute of Dental and Craniofacial Research (NIDCR), and Office of the Director (OD). W. M. Keck Research Foundation; Washington Research Foundation; Bio and Medical Technology Development Program, Korea.
|
Sources 2/ https://www.nih.gov/news-events/nih-research-matters/gum-disease-related-bacteria-tied-colorectal-cancer The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
