Health
Exploring early detection of Alzheimer's disease through non-cognitive symptoms
This article provides a thorough review of Alzheimer's disease (AD) and highlights the importance of early detection as the disease progresses stepwise from normal cognition to mild cognitive impairment (MCI) and ultimately to dementia. The review highlights the importance of identifying AD at the preclinical stage to prevent irreversible neurological damage and the need for accurate diagnostic methods that go beyond invasive and costly procedures such as lumbar puncture and PET imaging.
The review discusses a range of non-cognitive signs that may indicate the onset of Alzheimer's disease, including behavioral and psychological symptoms, sleep disorders, sensory impairments, and physical changes. Although these signs are not conclusive, they suggest that they may serve as early predictors of cognitive decline. The article also highlights the role of the gut. Microbiome The potential of blood-based biomarkers in the early diagnosis of AD.
The historical evolution of diagnostic approaches is detailed, showing a shift from a reliance on clinical evidence to the incorporation of biological indicators. The review outlines the evolution of diagnostic criteria, the introduction of biomarkers, and the potential impact of artificial intelligence in the discovery of new, minimally invasive biomarkers.
Certain non-cognitive signs, such as behavioral symptoms of dementia, circadian rhythm disruption, sensory impairment, and the impact of gut microbiota in AD, have been investigated in detail. The review points out the correlation between these symptoms and pathological changes in AD, suggesting a complex interplay between early signs and disease progression.
Progress Biomarkers Studies focusing on neuroimaging, blood-based markers, metabolomics, exosomal microRNAs, and the potential role of pathogens and endocrine dysregulation are highlighted. The review suggests that integrating these diverse biomarkers may significantly enhance early detection and disease management.
The correlation between non-cognitive symptoms and pathological changes is a key point of discussion, and this review highlights the bidirectional relationship between sleep disorders and AD, as well as the association between sensory impairments and brain regions affected early in the disease.
In conclusion, this review highlights the need for early detection for effective interventions and the potential of non-cognitive symptoms and biomarkers in identifying AD before cognitive decline becomes evident. We acknowledge the challenges of integrating these indicators into clinical practice and call for further research to confirm their reliability and applicability in early diagnosis.
The article concludes with a series of questions that highlight the need for further investigation into the use of non-cognitive symptoms as early indicators, the relationship of these symptoms to the underlying pathology of AD, and the possibility of integrating these indicators with biofluid biomarkers to improve diagnostic accuracy.
The search strategy and inclusion criteria outlined for this review focused on studies from the past 5–10 years related to AD, its biomarkers, and early diagnostic methods, with an emphasis on ensuring a comprehensive and up-to-date synthesis of current knowledge on early detection of AD.
sauce:
Journal References:
Chen, Y. Other(2024). Advances in early diagnosis of Alzheimer's disease. The cutting edge of medicine. doi.org/10.1007/s11684-023-1047-1.
|
Sources 2/ https://www.news-medical.net/news/20240826/Exploring-early-detection-of-Alzheimers-disease-through-non-cognitive-symptoms.aspx The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: cgurgu@internetmarketingcompany.BizWebsite: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or collaboration@support.exbulletin.com
 |
 |
 |
