Health
Kidney donor mortality rates plummet in 30 years
Top line:
The risk of perioperative mortality in living donors has decreased significantly over the past 30 years, with less than one death per 10,000 kidney transplants in the last decade. Male donors and donors with a history of previous kidney transplants are at increased risk. High blood pressure There was a high risk of death.
Methodology:
- Treatment trends in donor selection, perioperative care, and surgical techniques are evolving, and previous estimates of perioperative mortality may not reflect current risks. It is important that potential living kidney donors are informed of these updated risks.
- The researchers analyzed data from the Scientific Registry of Transplant Recipients on 164,593 living kidney donors from 1993 to 2022.
- Mortality rates within 90 days of organ donation were calculated and categorized into three eras: 1993–2002, 2003–2012, and 2013–2022.
- Mortality events were collected from multiple sources, including the Limited Access Mortality Master File provided by the Organ Procurement and Transplantation Network (OPTN) and the National Technical Information Service.
- Mortality risk was compared across subgroups by age, sex, race, ethnicity, type of procedure, BMI, and history of hypertension.
remove:
- The risk of perioperative mortality among living kidney donors was similar between 1993-2002 (3.0 per 10,000 kidney donations) and 2003-2012 (2.9 per 10,000 kidney donations) but decreased significantly between 2013-2022 (0.9 per 10,000 kidney donations). P = .01).
- The risk of death was higher for male donors than for female donors (4.0 vs. 1.0 per 10,000 donations).
- Donors with a history of hypertension had a higher mortality rate than donors without a history of hypertension (7.5 vs. 1.4 per 10,000 donations). P = .03).
- The risk of death was higher in donors undergoing open surgery (4.3 per 10,000 donations) than in donors undergoing laparoscopy (1.9 per 10,000 donations), but this difference was not statistically significant.
Exercise:
“Perioperative mortality after living organ donation has declined substantially over the past decade compared with previous decades, to less than 1 in 10,000 organ donations,” the authors write. “Current guidelines for donor informed consent, based on 2009 data, should be updated to reflect this information,” they add.
sauce:
The study was led by Dr. Alan B. Massey of the Department of Surgery at New York University Langone Health in New York City. Publish online August 28, 2024, JAMA.
Limitations:
The power of this study to estimate relative risk was limited by the small number of perioperative deaths over a 30-year period, and follow-up may have been incomplete, although stricter OPTN requirements since 2013 may have mitigated this issue.
Disclosure:
This research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Allergy and Infectious Diseases. Several authors reported receiving grant funding from the National Institutes of Health and/or receiving speaking, honoraria, or consulting fees from various pharmaceutical companies. One author reported serving as director of a scientific registry of transplant recipients.
This article was created using multiple editorial tools, including AI as part of the process; a human editor reviewed this content before publishing.
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Sources 2/ https://www.medscape.com/viewarticle/kidney-donor-mortality-plummets-over-30-years-2024a1000fop The mention sources can contact us to remove/changing this article |
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