Health
Pregnancy complications associated with increased risk of heart disease and stroke in later years
Comprehensive (Umbrella) analysis of data published by that pregnancy complications such as miscarriage, pre-eclampsia, gestational diabetes (gestational diabetes), and preterm birth are associated with an increased risk of heart disease in later years. Is suggested BMJ today.
Several other factors related to fertility and pregnancy also appear to be associated thereafter. Cardiovascular disease, Researchers say combined use, including early onset periods Oral contraceptives, Polycystic ovary syndrome, and premature menopause.
However, longer periods of breastfeeding reduce the risk of cardiovascular disease.
Previous studies have suggested that risk factors specific to women may be associated with cardiovascular disease and stroke, but the quality of the evidence and how findings can be translated into public health. There is a lack of clarity about what. Clinical practice..
As a result, a team of researchers in the United Kingdom searched relevant research databases for published systematic reviews and meta-analyses. Reproductive factors Women of reproductive age and the risk of subsequent cardiovascular disease.
A total of 32 reviews were included, assessing multiple risk factors over an average follow-up of 7-10 years.
Researchers found that early onset menstruation, combined use of oral contraceptives, Polycystic ovary syndrome, Miscarriage, stillbirth, pre-eclampsia, diabetes during pregnancy, premature birth, Low birth weight, And premature menopause were associated with up to twice the risk of cardiovascular outcomes.
Pre-eclampsia was associated with a four-fold risk of heart failure.
Possible explanations for these associations include family medical history, genetics, weight, hypertension and cholesterol levels, and chemical imbalances due to the use of hormonal contraceptives.
However, no association was found between cardiovascular outcomes and current use of progesterone-only contraceptives, use of parenteral hormone contraceptives, or fertility treatment.
In addition, breastfeeding was associated with a reduced risk of cardiovascular disease.
Researchers have pointed out some limitations, such as the fact that missing data and reviews are primarily based on observational evidence, which may have been influenced by other unmeasured (confounding) factors. Gender cannot be ruled out.
Nonetheless, they say the evidence reported in this comprehensive review suggests that women’s reproductive profile is associated with a future risk of cardiovascular disease from initial tide to menopause. I will.
It also clarifies the quality of evidence, identifies gaps between evidence and practice, and provides recommendations that can be incorporated into guidelines, such as reproductive integration. Risk factor As part of their risk assessment of cardiovascular disease, they conclude.
Association of Reproductive Health in Young Women with Cardiovascular Disease in Later Times: Umbrella Review, BMJ (2020). DOI: 10.1136 / bmj.m3502
Provided by
British Medical Journal
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