Health
Trial Discovers Unhelpful All-Dose Anticoagulants That Can Harm COVID Patients In ICU-Consumer Health News
Wednesday, December 23, 2020 (HealthDay News)-Anticoagulants are soon one of the daily cares of many inpatients, as COVID-19 is known to increase the likelihood of dangerous blood clots. It became a department.
However, in three clinical trials testing full doses of these drugs in COVID-19 patients, the recruitment of critically ill patients was suspended because the drugs could be more harmful than good.
According to experts from the National Institutes of Health (NIH), this finding is limited to COVID-19 patients who are ill enough to require care in the intensive care unit (ICU).
In a statement, NIH said in a statement, based on study results and recommendations from the monitoring committee responsible for patient safety in clinical trials, “All study sites have registered the most severely inpatients with COVID-19. It has been paused. ” Released on Tuesday.
“The trial will continue to enroll patients with COVID-19 who are moderately inpatients,” NIH added. This is because the benefits can outweigh the risks of patients who do not need ICU care.
According to NIH, the results of three previous trials show that all doses of anticoagulants Absent It seems to reduce the need for organ support in critically ill adult COVID-19 patients in the intensive care unit.
On the other hand, there can be potential harm. Increased bleeding is a complication of full dose use of anticoagulants.
A doctor at the forefront of the pandemic agreed that all doses of anticoagulants are dangerous.
“Low doses of anticoagulants may help both treat and prevent blood clots in patients with mild to moderate COVID-19, but high doses are associated with harm due to an increased risk of bleeding. It may be in the gastrointestinal tract, lungs, and brain. ” Dr. Robert Glatter, an emergency medical doctor at Lenox Hill Hospital in New York City, said. “Such abnormal bleeding can be fatal if not diagnosed and treated promptly.”
Further analysis of the data will be available as soon as possible, according to NIH.
Three tests are being conducted on four continents. Each compares the use of all doses of anticoagulants and the use of low doses, which are commonly used to prevent blood clots in inpatients.
These trials were initiated because healthcare providers found that many COVID-19 patients, including those who died of the disease, developed blood clots systemically, even with the smallest blood vessels. According to NIH, this abnormal coagulation can cause serious problems such as lung failure, heart attack, and stroke.
“By the recommendation of the Supervisory Board, patients who do not require ICU care at enrollment will continue to be enrolled in the study,” NIH said.
“Whether full-dose use compared to low-dose anticoagulants improves outcomes in inpatients with low COVID-19 severity remains a very important issue. Another medical indication. Patients who need the full dose of anticoagulant for this are not included in these trials, “NIH said.
Dr. Teresa Murray Amato is Chairman of Emergency Medicine at Long Island Jewish Forest Hills, also in New York City. In response to the NIH announcement, she said, “As we learn more about the COVID-19 virus, we continue to seek cures.”
She emphasized that all doses of anticoagulants may still play a role in the care of inpatients who do not require ICU care.
“We are continuing our research in less severe patients in the hope that they will continue to develop safe and effective treatments,” Amato said.
For more information
The US Centers for Disease Control and Prevention COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears..
Source: Robert Glatter, MD, Emergency Doctor, Lenox Hill Hospital, New York City. Teresa Murray Amato, MD, Chair, Emergency Medicine, Long Island Jewish Forest Hills, New York City.National Institutes of Health, News Release, December 22, 2020
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