Health

COVID-19 cases useful for stem cells

A breakthrough discovery was made in the search for a cure for coronavirus disease (COVID-19) in 2019. Researchers at the Diabetes Institute (DRI) and Cell Transplant Center at the University of Miami, along with a team of international collaborators, say that infusion of umbilical cord-derived mesenchymal stem cells (UC-MSC) leads to death and recovery from severe cases of illness. time of.

Published in the journal Stem cell translation medicine, The randomized controlled double-blind trial included 24 participants who were hospitalized with COVID-19 and developed severe acute respiratory distress syndrome. All patients received placebo or two transfusions of 100 million mesenchymal stem cells delivered to each other within 3 days.

“The umbilical cord contains prodromal or mesenchymal stem cells and can provide therapeutic doses from a single umbilical cord to more than 10,000 patients. It has potential for use in cell therapy applications. Is a unique resource for cells under investigation, whenever an immune or inflammatory response must be regulated, “said research leader Camilo Ricordi. “We have been studying them with Chinese collaborators for over 10 years in type 1 diabetes, and there are currently more than 260 clinical studies listed on clinicaltrials.gov for the treatment of other autoimmune diseases. There is. “

The results of the study showed that stem cell transfusions were safe and there were no serious adverse events associated with infusion. Survival at 1 month after treatment was 91%, compared with 42% in the placebo group. Patients under the age of 85 who received treatment showed 100% survival in one month. More than half of the treated patients recovered within 2 weeks of treatment and were discharged. By day 30, more than 80% had recovered, compared to only 37% in the control group.

The team plans further research on stem cells and COVID-19, with a particular focus on treating people who are not yet severely ill. Researchers want to determine if blood transfusions can potentially prevent the progression of the disease. The Cell Transplant Center wants to create a repository of mesenchymal stem cells that can be distributed.

“Our results confirm the strong anti-inflammatory and immunomodulatory effects of UC-MSC. These cells clearly suppressed the” cytokine storm “characteristic of severe COVID-19.” Said Giacomo Lanzoni, the lead author of the paper. “This result is very important not only for COVID-19, but also for other diseases characterized by an abnormal and hyperinflammatory immune response, such as autoimmune type 1 diabetes.”

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