Health
Bacteria can become more tolerant of antibiotics by transformation
A new study, led by Associate Professor of Physics at Carnegie Mellon University, shows how certain types of bacteria can adapt to long-term exposure to antibiotics by changing their shape. This work was published in Nature Physics today.
Adaptation allows organisms to better adapt their properties and behavior to the environment, whether it is the famous variety of finch observed by pioneering biologist Charles Darwin or the many types of bacteria in which humans coexist. It is a basic biological process that turns into. Antibiotics have long helped people prevent and treat bacterial infections, but it is becoming increasingly possible for many types of bacteria to adapt to resist antibiotic treatment.
Banersey’s work at Carnegie Mellon University and University College London (UCL) focuses on the mechanics and physics behind various cellular processes, and a common theme in his work is the shape of the cells. Breeding and survival. Together with researchers at the University of Chicago, he decided to delve into how exposure to antibiotics affects the growth and morphology of the commonly used model organism Caulobacter Crescentus.
“Using single-cell experiments and theoretical modeling, we show that cell shape changes serve as a feedback strategy for better adaptation of bacteria to surviving antibiotics,” Banersey said. Described what the collaborators found.
When exposed to the sublethal dose of the sublethal antibiotic chloramphenicol for multiple generations, researchers have found that the wider and more curved bacteria change their shape dramatically.
“These shape changes allow the bacteria to overcome the stress of antibiotics and resume rapid growth,” said Banergie. Researchers develop a theoretical model that shows that these physical changes cause bacteria to achieve higher curvatures and lower surface-to-volume ratios, and fewer antibiotic particles pass through the cell surface as they grow. By doing so, I came to this conclusion.
“This insight has significant implications for human health and is likely to stimulate more molecular research on the role of cell shape in bacterial growth and antibiotic resistance,” Banergie said.
reference
Banerjee S, Lo K, Ojkic N, Stephens R, Scherer NF, Dinner AR Mechanical feedback facilitates bacterial adaptation to antibiotics. Nature Physics.. Published online January 4th, 2021st, 1-7th. Doi:10.1038 / s41567-020-01079-x
This article was republished from material.. Note: The material may have been edited in length and content. Please contact the citation source for more information.
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