Health
Studies show that not all “good” cholesterol is healthy
Studies led by a team of researchers show that not all good cholesterol is now healthy.
A study led by the Hospital del Mar Medical Research Institute (IMIM) was published in the journal Metabolism, Clinical and Experimental.
Drugs that lower bad cholesterol reduce cardiovascular risk, but drugs that raise good cholesterol have not been proven to be effective in reducing the risk of heart disease. This paradox casts doubt on the relationship between good cholesterol and cardiovascular risk, and researchers are now studying the properties of good cholesterol particles.
HDL cholesterol (high density lipoprotein cholesterol) or good cholesterol is associated with a reduced risk of cardiovascular disease because it transports cholesterol deposited in the arteries to the liver for removal. This is in contrast to the so-called bad cholesterol, LDL (low density lipoprotein cholesterol), which accumulates cholesterol in the arteries and increases cardiovascular risk.
Researchers at CIBER on Cardiovascular Diseases (CIBERCV), CIBER on Obesity and Nutrition (CIBEROBN), CIBER on Epidemiology and Public Health (CIBERESP), and Hospital Clinic Researchers-IDIBAPS, IDIBELL, Hospital de la Santa Creu I Sant Pau Research Institute And Zaragoza’s Hospital Clinico Universitario also participated in this study.
In this study, researchers analyzed the genetic characteristics that determine the size of good cholesterol particles and studied their relationship to the risk of myocardial infarction. The conclusion is that the genetic features associated with the production of large good cholesterol particles are directly associated with an increased risk of heart attack, whereas the characteristics associated with small good cholesterol particles are associated with a low risk of heart attack. It means that they are related.
“There is a positive causal link between the size of HDL cholesterol particles and the risk of heart attack, so we need to raise the levels of good cholesterol in the blood, but they must always be small particles.” The principal investigator of the study explained. Dr. Robert Erosua, Hospital Delmar-IMIM, CIBERCV, and University of Vic-Researcher at the University of Central Catalonia (UVic-UCC).
Good cholesterol particles are more effective at transferring cholesterol to the liver and can eliminate cholesterol. “If you need to do something related to HDL, it’s a number of particles that properly perform the function of removing cholesterol, particles that actually move to the liver for removal, and small particles that don’t allow it. Increasing it accumulates in the arteries and causes cardiovascular disease, “said Dr. Alvaro Hernaez, a researcher at IDIBAPS and CIBEROBN.
Currently, there are no drugs that raise good cholesterol levels and reduce the risk of cardiovascular disease. “This study highlights new potential therapeutic targets in the field of cardiovascular disease, including several genes related to the qualitative aspects of HDL particles that may contribute to cardiovascular prevention.” Dr. Albert Platts, a researcher in epidemiology and cardiovascular genetics research, concluded. Hospital del Mar-IMIM group and lead author of research.
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