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Coronavirus outbreak: AIIMS scan for infectious diseases after vaccination

Coronavirus outbreak: AIIMS scan for infectious diseases after vaccination

 


A study of 63 so-called “breakthrough infections” in people vaccinated with the Covid-19 vaccine, conducted at the All Indian Institute of Medical Science in New Delhi, found high viral load and stable disease. However, no one has died.

A follow-up study of 63 Covid-19 patients who visited the AIIMS emergency department was also the first to record a breakthrough infection after administration of the homemade Covid-19 vaccine, Covaxin. ..

Previous breakthrough infections in India have been reported among recipients of Covishield, another vaccine currently in use in national vaccination campaigns.

According to researchers at the Institute for Genome Integrated Biology, who worked with AIIMS, the patient went to the emergency department for illness, but the illness did not worsen, the biomarkers were stable, and all survived.

“The zero mortality observed in this series of breakthrough infections is new evidence of vaccine protection,” a medical researcher at the institute told Telegraph.

Of the 63 patients, 53 received Covaxin and 10 received Covishield. Researchers claim that their study was not designed to measure the difference in breakthrough infections between the two vaccines.

Twenty-four patients were healthcare professionals at AIIMS, an institution that only provides Covaxin. Many others are locals and may have been vaccinated with AIIMS.

Of the 63 patients, 36 took 2 doses and 27 took 1 dose. Researchers have found that patients have high viral load, regardless of the status of the vaccine or the vaccine they receive.

Some patients also showed high levels of antibodies, so researchers said they “questioned the protection provided and their clinical relevance” to the number of antibodies against immunity from Covid-19.

Vaccine science experts have previously emphasized that vaccination is expected to produce other immune responses that can fight the coronavirus, rather than functioning only through antibodies.

The AIIMS-IGIB study also determined the genomic sequences of coronavirus specimens available from 36 of 63 breakthrough infections, with 23 (63%) variants designated as B.1.617.2. Turned out.

However, the proportion of variants in the samples from breakthrough infections was similar to the proportion of Covid-19 samples collected in Delhi in March and April.

“Similar proportions indicate that B.1.617.2 appears less frequently as a breakthrough infection. The epidemic seems to be seen in the general community,” said senior researchers.

AIIMS clinical microbiologist Urvashi Singh and IGIB scientist Sridhar Sivasubbu led a study involving 18 people, including AIIMS director Randeep Guleria and IGIB scientist Vinod Scaria. Researchers posted their research on bioRxiv, a preprint online server, on Thursday.

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