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TAU researchers develop ways to fight antibiotic-resistant bacteria

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Researchers at Tel Aviv University (TAU) has developed a process by which “good” viruses can attack the “bad” bacterial system, according to a university statement. The method discovered is by inhibiting the bacterial DNA replication mechanism. It can destroy the bacterial DNA without damaging it and affect its ability to replicate. It can be presented for a better understanding of the bacterial mechanism to distinguish and avoid good and bad bacteria. Fight Bacteria Using Bacterial Appliances and Bacterial Purges. Bacterial antibiotic resistance is a challenge faced by many scientists today. TAU researchers A potential solution to this problem lies in further investigation of the processes discovered, and most importantly, the “bacteriophage mechanism for taking over bacteria as the basis for the development of new tools to combat bacterial pathogens.” Researchers have elucidated this mechanism and discovered that bacteriophage proteins act with bacterial DNA repair proteins to “cleave the bacterial DNA being repaired,” TAU said. “Bacteriophage uses bacterial DNA,” added TAU. Bacteriophage itself does not require this type of repair, but said Udi Qimron, one of the lead authors of the study. I will. “In this way, bacteriophage destroys bacteria without damaging themselves.” “The ability to distinguish oneself from others is very important in nature and in a variety of biological applications,” Kimron added. “Therefore, for example, all antibiotic mechanisms identify and neutralize only bacteria and minimize their effects on human cells. Another example is with minimal self-injury, It is our immune system that causes maximum damage to foreign factors. ”The process of searching for types of bacterial variants that are not affected by this mechanism, that is, the process of searching for the types of bacterial variants that have developed immunity to it. Led to the discovery of specific bacterial mechanisms affected by the hijacking of bacteriophage.

“We have found that mutants of” immune “bacteria simply stop DNA repair and evade the bacteriophage destruction mechanism in a way that is vulnerable to bacteriophage attack. It’s a tool for endless fighting antibiotic-resistant strains, “Qimron concludes. Survey results In the scientific journal PNAS-Proceedings of the American Academy of Sciences.

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