Health
How New Ovarian Cancer Treatment Promises Effective and Efficient
Preclinical trials of new radiopharmaceuticals to treat ovarian cancer have been successful in dramatically limiting tumor growth and reducing tumor volume. Designed specifically for ovarian cancer that is resistant to conventional treatments, new radiopharmaceuticals can be manufactured in 25 minutes at low cost and are more efficient than other methods.
This study was presented at the 2021 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.
According to the American Cancer Society, more than 20,000 women are diagnosed with ovarian cancer each year, and nearly 14,000 die from the disease. The 5-year survival rate for ovarian cancer patients is 49.1%. It is the fifth leading cause of cancer death in women.
In this study, researchers leveraged a new generator system to develop targeted alpha therapy Pb-214-TCMC-trastuzumab for the treatment of HER2-positive ovarian cancer. Mice bearing ovarian cancer cells and ovarian cancer tumors were divided into three groups: a group treated with Pb-214-TCMC-trastuzumab, a group treated with Pb-214-TCMC-IgG, and an untreated control group. All groups were imaged over time to determine the effectiveness of the treatment.
Tumor signals in mice and cells treated with Pb-214-TCMC-trastuzumab were dramatically reduced during the course of the study, demonstrating therapeutic efficacy as compared to Pb-214-TCMC-IgG and the control group. It was. There were no adverse side effects of treatment, as determined by the weight loss of all living animals.
“The short half-life of Pb-214 of 27 minutes is ideal for fractional alpha particle therapy applications,” said Mike Zamiara, research author and president of Niowave Inc. in East Lansing, Michigan. .. “The generator system can provide Pb-214 per hour, which has the potential to provide patients with a new source of alpha particle therapy at a lower cost. In the future, generator systems will be available in many turnkey systems, including: It will be available in therapeutic products. We will continue to develop and provide reliable doses to improve patient care. “
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What Are The Main Benefits Of Comparing Car Insurance Quotes Online
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