Health
Description: Studies have linked South Asian descending genes to higher Covid risk.Here are some important discoveries
This gene (called LZTFL1) is found in 60% of people with South Asian ancestry, and researchers have found the excessive mortality seen in parts of the British community and the effects of a pandemic in the second wave of India. It states that it may be possible to explain.
Still, genes are probably one of the factors that can lead to these consequences, as socio-economic factors partially explain why some communities have been more severely affected by the disease. Not too much.
For example, 60% of people with South Asian ancestry carry this gene, 15% of people with European ancestry have it, and 2% of people with Afro-Caribbean ancestry also carry it. I’m waiting. Therefore, this gene does not explain the high mortality reported in blacks and some ethnic minority communities.
This study was published in Nature Genetics this week.
the study
In this study, researchers used state-of-the-art technology to look at genes that increase the risk of death from COVID-19 for people under the age of 65 and how this gene led to this result. The team first trained artificial intelligence algorithms. It analyzed vast amounts of genetic data from hundreds of cells from all parts of the body. This indicates that this genetic signal is likely to affect the cells present in the lungs.
How does a gene make people who have it more vulnerable to disease?
They found that a high-risk version of the gene could prevent the cells that line the airways and lungs from responding properly to the virus. This means that the presence of this gene changes the way an individual’s lungs respond to the virus, thereby increasing the risk of developing respiratory failure from COVID-19.
However, genes affect the response of the lungs, but not the immune system. Therefore, researchers believe that anyone with this version of the gene should respond normally to the vaccine.
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“Although genetics cannot be changed, our results show that people with high-risk genes are particularly likely to benefit from vaccination. Genetic signals are sent to the lungs rather than the immune system. To impact, the increased risk means that the vaccine should offset it, “said Professor James Davis, co-leader of the study.
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