Health
IIT Mandy researchers discover drug molecules to treat diabetes
Can be a major breakthrough in Diabetes mellitus Treatment, Indian Institute of Technology, Mandy Team has discovered a drug molecule that can be used to treat diabetes. This molecule, called “PK2,” can cause the pancreas to release insulin and may be used as an oral drug for diabetes.
In a statement, IIT Mandi said, “The research results have been published in the Journal of Biological Chemistry. This paper was written by Dr. Prosenjit Mondal, an associate professor of the Faculty of Basic Sciences, and co-authored by Professor Subrata Ghosh. Department, IIT Mandy. ”
Dr. Mondal explained the rationale for their study: “Current drugs used for diabetes, such as exenatide and liraglutide, are given as injections and are expensive and unstable after administration. We are stable. We aim to find a simpler drug that is cheaper and cheaper. It is effective against both type 1 and type 2 diabetes. ”
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“Diabetes is associated with inadequate insulin release by pancreatic beta cells in response to blood glucose levels. Insulin release involves many complex biochemical processes. One such process. Contains a protein structure called GLP1R that is present in the cell, “he said.
He further stated that a hormone molecule called GLP1, which is released after eating a meal, binds to GLP1R and causes the release of insulin. “Drugs such as exenatide and liraglutide mimic GLP1 and bind to GLP1R to induce insulin release,” he said.
“To find alternatives to these agents, the multicenter team first used computer simulation methods to screen for a variety of small molecules that could bind to GLP1R. PK2, PK3, and PK4 are good with GLP1R. However, they chose PK2 afterwards. The solubility in the solvent was improved. Then, the researchers synthesized PK2 in the laboratory for further testing, “IIT Mandy said. Stated in a statement.
Dr. Prosenjit Mondal points out another important finding in their research. “”
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To test the biological effects of PK2, IIT Mandi said in a statement that researchers were orally administered to mice with diabetes to measure glucose levels and insulin secretion.
“Serum insulin levels in PK2-treated mice increased 6-fold compared to the control group. These findings provide hope for cheap oral medications for diabetics,” said IIT Mandy.
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