Health
Cedars-Sinai Fights Severe Coronavirus Symptoms With Arthritis Remedy – Daily News
LOS ANGELES — Most patients hospitalized with COVID-19 pneumonia experienced improvement after receiving a US Food and Drug Administration-approved drug commonly used for rheumatoid arthritis, according to a new study Tuesday by Cedars-Sinai Medical Center Reported based on.
Outcomes of patients treated with tocilizumab included inflammation, oxygen requirements, blood pressure support, and a reduced risk of death compared to reports of illness and death associated with severe COVID-19 patients. It was
In a statement, Cedars said in a single-institution observational study of 27 patients was conducted clinically on June 23, led by Dr. Stanley Jordan, director of the Cedars-Sinai Nephrology and Transplant Immunology program. It was announced in an infectious disease.
Patient outcomes were promising, but researchers are insufficient to demonstrate the safety and efficacy of the drug in COVID-19 patients because they did not conduct clinical trials with controls I said.
The team targeted 27 COVID-19 pneumonia patients who received the immunosuppressant tocilizumab to delay an uncontrolled immune response, including oxygen levels, blood pressure, and the need for medications to increase patient survival. We investigated laboratory and clinical changes. The researchers observed improvements in inflammatory markers and patient survival and compared with reports of patients not treated with tocilizumab.
“The researchers have been studying tocilizumab for 10 years, focusing on its use in cytokine storms associated with rheumatoid arthritis and cancer,” said Jordan, professor of medicine at Cedars-Sinai. The drug was approved by the FDA in 2010 for the treatment of rheumatoid arthritis.
Researchers at Cedars-Sinai have discovered that interleukin 6, a protein that stimulates immune cell production and is a target of tocilizumab, is the major cytokine elevated in COVID-19 patients.
“We infer that tocilizumab blocks interleukin 6 so it makes sense to try it in patients with COVID-19 pneumonia,” said Jordan.
Cytokines are molecules secreted by multiple cell types, including cells of the immune system that regulate the body’s immune response. A cytokine storm is a serious reaction in which immune cells are flooded and attack healthy organs that should protect them. In COVID-19 patients, the virus stimulates immune cells, causing collateral lung injury. This can leak blood vessels and cause blood to clot. The patient’s blood pressure drops and the organs fail.
Early in the COVID-19 pandemic, health professionals discovered that a cytokine storm was causing rapid deterioration in some patients. The key to the survival of patients the researchers are learning is to prevent the storm from gaining power.
Most patients who received tocilizumab were on a ventilator to support their breathing. Each of them received one dose of tocilizumab. This helps block the signaling of the cytokine interleukin-6. It is the only cytokine detected in harmful amounts in all study patients.
“The more interleukin 6 present in the body, the worse the patient’s outcome,” Jordan said.
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