Health
High-dose psilocybin shows promising results for depression
Top line:
High doses of psilocybin are not a placebo or EscitalopramA new meta-analysis suggests there is no increased risk of serious adverse events.
Methodology:
- The researchers conducted a network meta-analysis to evaluate the comparative effectiveness of psychedelics versus oral escitalopram monotherapy in clinically diagnosed patients. depression.
- The meta-analysis included 811 participants with clinically diagnosed depression (mean age 42.49 years, 54.2% women) from 15 psychedelic drug trials and 1968 participants (mean age 39.35 years, 62.5% women) from five escitalopram trials.
- The trials evaluated oral psychedelic monotherapy (psilocybin, lysergic acid diethylamide, and 3,4-methylenedioxymethamphetamine). [MDMA]ayahuasca), fixed doses of escitalopram (up to 20 mg/day) versus placebo, and hallucinogens versus escitalopram monotherapy were compared.
- The primary outcome was change in depressive symptoms from baseline.
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- Placebo responses in antidepressant trials (mean difference, 3.79; 95% CI, 0.77-6.80) and very low-dose psilocybin (mean difference, 3.96; 95% CI, 0.61-7.17) were better than responses in hallucinogen trials.
- High-dose psilocybin (≥20 mg) was shown to be more effective than placebo in antidepressant trials (mean difference, >3). However, effect sizes were smaller when comparing the high-dose psilocybin used in antidepressant trials with placebo; the standardized mean difference decreased from 0.88 to 0.31, indicating that the efficacy of high-dose psilocybin is comparable to that of current antidepressants.
- Higher doses of psilocybin produced greater responses than escitalopram at 10 mg (4.66; 95% CI, 1.36-7.74) and 20 mg (4.69; 95% CI, 1.64-7.54).
- No intervention was associated with an increased risk of all-cause withdrawal or serious adverse events.
Exercise:
“Taken together, our findings suggest that among psychedelic treatments, high doses of psilocybin are likely to reach minimally important differences in depressive symptoms in studies with appropriate blinded designs. Meanwhile, the effect size of psilocybin is similar to that of current antidepressants, showing a mean standardized difference of 0.3,” the authors write.
sauce:
The study was led by Tien-Wei Hsu, M.D., Ph.D., of I-Shou University and Kaohsiung Medical University in Kaohsiung, Taiwan. Publish online On August 21 BMJ.
Limitations:
The study did not evaluate the long-term effects of the intervention. Participants in the MDMA trial were primarily diagnosed with post-traumatic stress disorder, which may not be representative of the general population with depressive symptoms. Additionally, the sample size of the hallucinogen trial was small. By using very low doses of hallucinogens as the reference group, some pharmacological effects may have been eliminated, as these doses would not be considered placebo.
Disclosure:
This research was supported by a grant from the National Science and Technology Council. The authors declared that they have no financial relationships with any organization outside the submitted work within the past 3 years. Full disclosures can be found in the original article.
This article was created using multiple editorial tools, including AI as part of the process; a human editor reviewed this content before publishing.
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Sources 2/ https://www.medscape.com/viewarticle/high-dose-psilocybin-shows-promising-results-depression-2024a1000fqw The mention sources can contact us to remove/changing this article |
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