Health
Research says HCQ does not work as a prophylactic antiviral against Covid-19
New research suggests that the famous antimalarial drug Hydroxychloroquine (HCQ) is not a possible defense against Covid-19.
The study, published in the journal Annals of the Rheumatic Diseases, found that HCQ was not effective in preventing COVID-19 in patients with lupus and rheumatoid arthritis (RA), suggesting a broader interpretation of HCQ. It suggests that it is an ineffective preventive drug for the general public.
“Our research shows with great confidence that HCQ is ineffective and at high risk as a prophylactic antiviral drug because SLE and RA are taking drugs that suppress the immune system. “Mendel Singer, research lead author, said. Case Western Reserve University of America.
Many researchers are focusing on patients with systemic lupus erythematosus (SLE) and RA. This is because HCQ is frequently ingested by patients. In an early pandemic case report, these patients were not receiving Covid-19.
Later, previous researchers investigated HCQ in the lab and found that it was effective against the virus, in addition to its already established anti-inflammatory properties, so testing people for prevention or treatment would At first there was some promise. Since these early tests, various recent studies have shown that HCQ is ineffective in treating moderate to severe hospitalized cases. Treatment with HCQ for early-stage or mild cases of the disease is still under consideration.
The research team used a large national database to pull anonymized patient data from 36 healthcare systems, compile a much larger study than previous studies, and analyze SLE and RA patients and HCQs. We examined their health outcomes related to their use. In previous studies, less than 20 patients with SLE and/or RA had Covid-19. There were 159 in this study. The study showed that patients with SLE and RA who developed Covid-19 were likely to take HCQ as well as patients with SLE and RA who did not have Covid-19. ..
“By leveraging data from a relatively large population of patients with lupus and/or RA, we can provide a higher level of confidence in our findings,” Singer said.
“This large retrospective review found that the drug was ineffective in preventing Covid-19 in these patients taking HCQ,” if HCQ was effective in preventing it. , Was a patient with SLE / RA Covid-19 taking HCQ, but not,” the authors write.
“This means that HCQ is not active against the SARS-CoV-2 virus in humans (rather than in the lab) and is unlikely to be an effective prophylactic antiviral drug for anyone. There is a possibility,” they said.
A study published last month in the Annals of Internal Medicine showed that HCQ was also ineffective in Covid-19 patients with early and mild symptoms.
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(Only the headlines and photos in this report may have been rewritten by Business Standard staff. The rest of the content is auto-generated from syndicated feeds.)
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