Health
covid-19: The study states that the new coronavirus may undergo mutations that can be more deadly and contagious.
However, studies published in the journal mBIO did not find that these mutations were fatal to the virus or altered clinical outcomes.
Researchers noted that a mutation called D614G is in a spike protein that breaks open cells for virus invasion.
“The virus mutates due to a combination of neutral drift (meaning random genetic changes that don’t help or hurt the virus) and pressure from the immune system,” said Ilya Finkelstein, an associate professor at the University of Texas. I have. ” In Austin, Texas, USA.
During the first wave of the pandemic, researchers said 71 percent of the novel coronaviruses identified in Houston patients had this mutation.
They said the variant had jumped to a prevalence of 99.9 percent when the second wave of outbreaks struck Houston during the summer.
According to researchers, this reflects trends observed around the world.
The reason why strains containing this mutation outperform those without it is Natural selection Researchers said they favored more susceptible strains of the virus.
However, some scientists have proposed another explanation called the “founder’s effect.”
In that scenario, the D614G mutation could have been more common in the first viruses that arrived in Europe and North America, and researchers said it was essentially a good start in other strains.
Spike proteins also continue to accumulate additional mutations of unknown importance, they said.
The team also demonstrated in laboratory experiments that at least one such mutation allows spikes to evade human-generated neutralizing antibodies to combat SARS-CoV-2 infection.
Researchers said this could make it easier for mutants of the virus to slip through the immune system.
It’s not yet clear if it will be more easily transmitted between individuals, but they said.
Scientists have pointed out a total of 285 mutations across thousands of infections, most of which do not appear to have a significant effect on the severity of the disease.
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