Health
This area of the brain promotes patience
Researchers have identified specific areas of the brain that individually promote patience through the action of serotonin, a chemical produced by the body.
This study, published in the journal Science Advances, is becoming more important in light of the fact that learning to curb the urge to immediate satisfaction is often essential to future success, but patience is in the brain. I’m not sure how it’s regulated.
“Serotonin is one of the most famous neuromodulators of behavior and helps regulate mood, sleep-wake cycle, and appetite,” said research co-author Katsuhiko Miyazaki of Okinawa Institute of Science and Technology Graduate University. Stated.
In studies on mice, serotonin-releasing neurons from the nucleus accumbens (DRN) penetrate many other areas of the brain, including the nucleus accumbens (NAc), orbitofrontal cortex (OFC), and medial prefrontal cortex (mPFC). Was shown.
“Our research shows that the release of this chemical messenger also plays an important role in promoting patience, increasing the amount of time mice wait for food rewards.”
This study resembles a previous study in which the unit used a powerful technique called optogenetics, which uses light to stimulate specific neurons in the brain, to establish a causal relationship between serotonin and patience. I use it a lot.
In previous studies, scientists focused on a region of the brain called the dorsal raphe nucleus, which is the central hub of serotonin-releasing neurons.
Neurons from the dorsal raphe nuclei reach other regions of the forebrain, and in their latest study, scientists specifically investigated which of these other brain regions contributed to the regulation of patience. Did.
Researchers have found that serotonin stimulation in the orbitofrontal cortex is almost as effective as stimulation in the dorsal raphe nuclei, whereas it does not promote waiting in the nucleus accumbens.
They also found that serotonin stimulation of the medial prefrontal cortex promotes wait only when the timing of future rewards is uncertain.
“These results suggest that while mPFC serotonin influences the assessment of committed time, OFC serotonin is involved in the overall assessment of late rewards,” the researchers said. writing.
Ultimately, increasing knowledge of how different areas of the brain are more or less affected by serotonin can have significant implications for future drug development.
For example, selective serotonin reuptake inhibitors (SSRIs) are drugs that increase serotonin levels in the brain and are used to treat depression.
“This is an area we would like to explore in the future using a mouse depression model,” says Miyazaki.
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