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Indonesia is committed to eliminating lymphatic filariasis in the form of a public health problem

 


Indonesia has recently completed the most recent annual comprehensive treatment for lymphatic filariasis (also known as elephantiasis or Penyakit Kaki Gajah) in Malaka district located in the southernmost province of East Nusa Tenggara. Unprecedented
the progress of the National Lymphatic Filariasis Removal Program has strongly set the country on track to achieving lymphatic filarial removal as a public health problem.

“We have reached an estimated 40.7 million people living in 118 high-risk neighborhoods during a multi-month treatment campaign in October 2019.“Said Dr Anung Sugihantono, who recently stepped down as Managing Director for Diseases
Prevention and Control, Ministry of Health Indonesia. “
Single doses of WHO-enabled diethylcarbamazine citrate and albendazole were delivered to all eligible populations. “

In 2010, about 125 million Indonesians were still at risk of disease and required treatment.

But things changed significantly in 2015 when Indonesia launched an annual national campaign to decisively address the transmission of disease and combat its morbidity and disability. The results were already visible in 2017, p
remarkable progress.

In Indonesia, LF is considered a significant public health concern. Risk mapping in 2009 identified a population of 124.5 million people in need of treatment for LF. The country launched a campaign to eliminate LF nationally in 2015, addressing both
disease prevention and management.

“In 2017 and in just two years, we were able to achieve 100% geographical coverage of all people in need of treatmentsaid Dr. Sugihantono. “This meant reaching over 78% of epidemiological coverage – much higher than the generally recommended 65% for stopping transmission.”

Transmission of lymphatic filariasis can be stopped by extensive treatment (or mass drug administration – MDA) of entire risk communities with recommended medications once a year. These drugs kill microfilariae in infected patients
blood that prevents mosquitoes from transmitting1 illness to others. The goal of mass treatment is to reduce the reservoir of microfilariae in the blood to a level insufficient to maintain mosquito transmission.

This transfer interruption strategy is a cornerstone of the World Health Organization’s (WHO) Global Lymphatic Filariasis (GPELF) program. Indonesia has been using the GPELF strategy since 2002 using a district or city
as its implementing unit.

In 2005, eliminating LF was cited as a national priority in the control of infectious diseases, and the drugs he used in major treatment programs were diethylcarbamazine citrate (DEC) and albendazole.2 which are
largely distributed by community health volunteer workers3.

“Community health volunteers are members of the community themselves and know how to effectively engage people to improve compliance“Said Dr. Stefanus Bria Seran, Regent of Malacca District, one of Indonesia’s endemic LF districts. “In addition to ensuring that each individual is given the medication they are given, these community workers help to disseminate information prior to a major treatment campaign and also assist in reporting activities related to each treatment campaign.”

Indonesia’s efforts to eliminate lymphatic filariasis began in the 1970s, but faced many challenges, including coordinating programs in many populated islands, implementing information, education and awareness programs, lack of capacity and
not enough medication.

Furthermore, the situation in Indonesia is more unusual than in many other countries endemic to lymphatic filariasis because the country is endemic to all three species of filamentous filarial worms – Brugia malayi, Brugia timors, i Wuchereria bancrofti
which cause disease. Most infections in Indonesia, however, cause it B. malayi.

In the past, some of the factors preventing access to medicines (DEC and albendazole) were disease-related social stigmatization, the vast geography of the territory, and the challenges of reaching a remote population.

With an estimated population of 242 million, Indonesia is the world’s largest island nation and consists of approximately 17,000 islands, 5,000 to 6,000. The fourth most populous country behind China, India and the United States
States.

Indonesia is endemic to many other neglected tropical diseases, with an estimated 110 million Indonesians suffering from at least one neglected tropical disease (NTD), including lymphatic filariasis and helminthic soil-borne infections.
Leptospirosis (not classified as NTD) is also widespread.

Indonesia is thIt is the only Southeast Asian country in the WHO region with endemic schistosomiasis. Like many other countries in the Region, it also faces repeated threats of a dengue epidemic.

Global progress

The world has made significant progress toward eliminating lymphatic filariasis as a public health problem.

Sixteen countries5 and the WHO recognized one territory that eliminated lymphatic filariasis as a public health problem.

Seven additional countries have successfully implemented the recommended strategies, halted large-scale treatment and have monitored the elimination achieved.

Disease

Lymphatic filariasis is caused by infection with parasitic worms that live in the lymphatic system. Parasite larvae (microfilariae) circulate in the blood and mosquitoes are transmitted from person to person.

Infection includes asymptomatic, acute and chronic conditions. Most infections are asymptomatic, showing no outward signs while contributing to the transmission of the parasite. Although asymptomatic, these infections still cause damage to the lymph
system and kidneys and alter the body’s immune system.

When lymphatic filariasis develops into chronic conditions, it leads to lymphedema (tissue swelling) or elephantiasis (skin / tissue thickening) of the limbs and hydrocele (eardrum). The involvement of the breast and genital organs is common.

Manifestation of illness after infection is time consuming and can result in altered lymphatic system, causing abnormal enlargement of body parts and leading to serious disability and social stigmatization of the diseased.


1Lymphatic filariasis is transmitted by different types of mosquitoes – e.g. Culex mosquito that is widespread in urban and semi-urban areas; Anopheles, is mainly found in rural areas; and, Aedes, mostly
in the endemic islands in the Pacific.

2In 2017, the WHO recommended alternative treatment for the three drugs to accelerate the global removal of lymphatic filariasis. The treatment, known as IDA, involves a combination of ivermectin, diethylcarbamazine citrate and albendazole.
It is recommended annually in environments where its use is expected to have the greatest impact.

3Community health workers, also called human resources, are volunteers who form part of the communities they serve and work with
community education communities. Their contribution to promoting health is significant in the country.

4Cambodia, Cook Islands, Egypt, Kiribati, Maldives, Marshall Islands, Niue, Palau, Sri Lanka, Thailand, Togo, Tonga, Vanuatu, Vietnam, Wallis and Futuna and Yemen

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