Health
Questionable value of colorectal cancer screening
- Mina JohanssonGeneral Practitioner and Director
- Global Center for Sustainable Healthcare, 45152 Uddevalla, Sweden
- minna.johansson{at}vgregion.se
Screening for colorectal cancer is widespread in high-income countries and strongly recommended in most guidelines.123 Evidence from randomized trials indicates that screening invitations with sigmoidoscopy or guaiac fecal occult blood test reduce mortality from colorectal cancer.Four However, the evidence to evaluate the most widely used screening tests, colonoscopy and stool immunochemistry, is limited to observational studies, modeling, and reasoning.Five
The NordICC trial, the first randomized trial of colonoscopy screening,6 was recently published, updating the BMJ Rapid Recommendation for Colorectal Cancer Screening (doi:10.1136/bmj.l5515).1 Approximately 85,000 people aged 55 to 64 years were randomly assigned to either be invited or not to undergo a one-time colonoscopy. After 10 years, screening invitation did not reduce mortality from colorectal cancer: 0.31% of the control group died of colorectal cancer compared with 0.28% of the screening invitation group (risk ratio 0.90 , 95% confidence interval 0.64 to 1.16).6 Although screening reduced the risk of developing colorectal cancer (risk ratio 0.82, 0.70 to 0.93), disappointing results for colorectal cancer mortality were …
Sources 2/ https://www.bmj.com/content/380/bmj.p200 The mention sources can contact us to remove/changing this article |
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