Human vision is restored through stem cell replacement, a breakthrough in regenerative medicine.

Researchers led by Japan's Osaka University have conducted the first human clinical trial to use induced pluripotent stem cell-derived corneal epithelium to treat limbal stem cell deficiency, opening new possibilities for restoring vision. provided sex.

Limbal stem cell deficiency (LSCD) is a severe eye disease that causes loss of function. adult stem cells Infiltration of the fibrous conjunctival tissue at the edge of the cornea into the cornea causes visual impairment. Limbal stem cells normally perform repair functions by differentiating into the corneal epithelium. Without them, the integrity and transparency of the corneal surface is compromised, leading to the accumulation of fibrotic tissue and ultimately vision loss.

Traditional treatments often involve transplantation from the patient's healthy eye or a donor, but these methods come with risks such as immune rejection or require removal of healthy tissue.

“The corneal epithelium derived from induced pluripotent stem cells is transplant surgery: A single-arm, open-label, first-in-human intervention study in Japan.” published in lancetResearchers implemented transplantation of pluripotent stem cell (iPSC)-derived corneal epithelial sheets (iCEPS) as a potential treatment for LSCD.

Four patients with LSCD participated in the study. After removing the fibrotic tissue, the team implanted allogeneic iCEPS into the affected eye. All surgeries were performed without any human leukocyte antigen (HLA) matching. Half of the patients received low doses of cyclosporine (usually used to reduce organ rejection after transplantation), and the other half received no immunosuppressants other than corticosteroids.

No serious adverse events were identified during 2 years of monitoring. Mild adverse events were effectively managed with no lasting effects.

All four patients experienced significant improvement in visual acuity. In three patients, the disease progressed to a less severe classification. One patient who had a more severe underlying disease initially improved to a less severe stage by 32 weeks, but returned to baseline after 1 year. Quality of life ratings were consistent with visual improvement, with 3 of 4 patients reporting improved scores.

Overall, this study demonstrated that iCEPS transplantation not only stabilizes the corneal surface but also restores functional vision and significantly improves the daily life of patients with limbal stem cell deficiency. The beneficial results were more pronounced in patients who received lower doses of cyclosporine, suggesting that the absence of cyclosporine may have caused subclinical immune rejection.

iCEPS were cultured using a method that recapitulates aspects of natural eye development to generate functional corneal cells. This technique not only ensures the structural integrity of the graft, but also reduces immunogenicity, potentially eliminating the need for HLA matching and extensive immunosuppression typically required with conventional grafts. There is.

This successful outcome represents a major therapeutic advance, building on earlier successes in treatment. regenerative medicine while overcoming the limitations of existing LSCD surgical treatments. The Osaka team plans to initiate a larger multicenter clinical trial to further validate the findings and explore the broader applicability of iCEPS implantation.

Detailed information:
Tsuyoshi Soma et al., Induced pluripotent stem cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human intervention study in Japan, lancet (2024). DOI: 10.1016/S0140-6736(24)01764-1

© 2024 Science X Network

quotation: Stem cell replacement restores human vision in breakthrough in regenerative medicine (November 12, 2024) https://medicalxpress.com/news/2024-11-human-vision-stem-cell-regenerative. Retrieved November 12, 2024 from html

This document is subject to copyright. No part may be reproduced without written permission, except in fair dealing for personal study or research purposes. Content is provided for informational purposes only.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos