Relationship between liver-brain communication and daily eating patterns

People who work night shifts, odd hours, and eat at irregular times are more likely to gain weight and develop diabetes. This is likely due to eating patterns that don't align with the timing of natural light or regular meal times. But despite being biologically unfavorable, is it possible to prevent the negative effects of eating at such “abnormal” times? Perelman School of Medicine He says yes and reveals how the body knows when to eat. This research science, It explains how researchers discovered the connection between the liver's biological clock and the brain's feeding center.

The researchers' research showed that the liver sends signals to the brain via the vagus nerve, telling the brain whether eating is occurring at a time that follows the body's circadian rhythm. These signals can be disrupted by working unusual hours. Your brain then overcompensates and ends up overeating at the wrong time.

“Both mice and humans typically eat when they are awake and alert. This circuit provides feedback from the liver to the brain's central clock to keep the system running smoothly,” the study says. said the lead author. Mitchell Lazar Director of Penn Medicine Diabetes, Obesity and Metabolism Research InstituteWare Professor of Diabetes and Metabolic Diseases. “This feedback occurs via neural connections from the liver to the brain.”

The researchers suggest that targeting specific parts of the vagus nerve could help people who work night shifts or are jet-lagged cope with overeating caused by disrupted body clocks.

This story is by Matt Tolle. read more penn medicine news.

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