Health
AeroNabs: New protection against COVID
The next promising treatment for COVID-19, reported in the latest bioRxiv on Tuesday, August 11, is a new synthetic and inhalable substance.
A team headed by the University of California San Francisco (UCSF) has developed an aerosol formation called “AeroNabs”. The AeroNabs molecule uses a “restraint jacket” that is an important SARS-CoV-2 mechanism that allows the virus to infect human cells. The results of the research awaiting peer review certification are now Preprint server bioRxiv..
(Photo: UCSF YouTube Channel)
Scientists at the University of California, San Francisco have devised a new approach to stop the spread of the disease-causing virus, SARS-CoV-2, as vaccines to control the COVID-19 pandemic are long awaited. Did.
Ultra-high affinity synthetic Nanobody
SARS-CoV-2Spike, a highly contagious disease behind the global coronavirus pandemic, initiates infection of human cells through its spike proteins. This spike protein interacts with the receptor angiotensin converting enzyme 2 (ACE2), a protein located on the surface of several cell types in the human body. As an enzyme, it divides the larger protein angiotensinogen into smaller proteins, which regulate numerous cellular functions.
It binds to the ACE2 receptor via surface viral spike proteins and initiates infection of other cells after ACE2.
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The UCSF research team points out that disrupting this interaction is a powerful way to neutralize the entry of the virus into the body and open up the potential for vaccine design and therapeutic antibodies.
Researchers have developed single domain antibodies, or Nanobodies, that “break” the interaction between the human ACE2 receptor and the SARS-CoV-2 Spike protein. By screening a large number of synthetic Nanobody sequences, we discovered a panel of these Nanobodies that bind and wrap to spikes.
AeroNabs: Molecular Personal Protective Equipment
The most effective was the nanobody labeled Nb6, which later evolved into mNb6-tri, a trivalent form with affinity for the SARS-CoV-2 spike. During testing, researchers found that trivalent Nanobodies remained stable after aerosolization, lyophilization, and heat treatment.
That is, the new SARS-CoV-2 antibody can be administered directly from the patient’s respiratory epithelium using the mechanism found in nasal sprays and inhalers. As a result of further research, we aim to make AeroNabs available at a lower cost than over-the-counter drugs in the prevention and treatment of COVID-19.
“Much more effective than wearable foam personal protective equipment, AeroNabs says that NaVbs act as an important temporary gap until the vaccine provides a more permanent solution to COVID-19,” said Peter Walter. Is considered to be the molecular form of Co-inventor of AeroNabs And the author of the study. Walter is a professor of biochemistry and biophysics at the University of California, San Francisco and a researcher at the Howard Hughes Medical Institute.
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The molecule that paved the way for AeroNabs was inspired by Nanobodies-a protein that mimics our antibodies and occurs naturally in llamas and camels. “They act like antibodies found in the human immune system, but Nanobodies offer many unique advantages in effective treatments against SARS-CoV-2,” Asshish Manglik, MD. , Ph.D. Explained. Manglik is a co-inventor of AeroNabs and an associate professor of pharmaceutical chemistry.
First of all, Nanobodies are significantly smaller than our antibodies, making them easier to work in the laboratory. Because they are smaller, Nanobodies often also employ simpler structures, which means more stability compared to more complex human antibodies.
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