Health
New HPV self-testing approach could enhance cervical cancer screening
Analysis of human papillomavirus (HPV) self-tests can be used to divide HPV-positive women into three risk groups, according to a new study from Karolinska Institutet and Queen Mary University of London published in the journal PLOS Medicine. It is said that it can be done. This method could be important for enhancing cervical cancer screening.
The study looked at British women who were recommended to self-test for HPV in a clinical trial because their cervical cancer screening deadline had passed.
“Self-testing for HPV has become an important component of cervical screening, reaching women who might not otherwise participate,” said the Department of Medical Epidemiology and Biostatistics and Department of Clinical Sciences. said Jiayao Lei, assistant professor in the Department of Intervention and Technology. I am the lead author of this study.
The study, carried out at a primary care center in the UK, included 855 women with a positive HPV self-test, meaning they had an HPV infection, and clinician samples were also subsequently taken. Seventy-one (8.3%) of these women were found to have severe cervical precancer or cancer.
Further investigation into high-risk groups
Researchers took a closer look at HPV test results in self-samples and used a new method to assess the risk of severe cell changes. Risk stratification is based on HPV viral variants and the amount of virus present during self-testing (measured as cycle threshold, Ct value). This was used to classify women into three risk groups: high-risk, medium-risk, and low-risk. Women with HPV type 16 and low Ct values (<30) had the highest risk of severe cervical precancer or cervical cancer.
Approximately 40% of women in our high-risk group had been diagnosed with severe cervical precancers or cancers that required treatment. Therefore, our recommendation going forward is to refer this group directly for further investigation by colposcopy. ”
Jiayao Lei, Assistant Professor, Department of Medical Epidemiology and Biostatistics and Department of Clinical Sciences, Interventions and Technology, Karolinska Institutet
More than half of those who tested positive were in the low-risk group, with a 4% chance of being diagnosed with severe precancerous or cervical cancer within 12 months.
“While we think it is safe for low-risk groups to be retested after 12 months, intermediate-risk groups should be encouraged to be tested by a clinician,” said study lead author Dr. Peter Sacieni, a professor at the University of Mary. .
Benefits of risk stratification
One of the main advantages of the new method is that risk assessment can be performed immediately after HPV self-testing and does not require further laboratory analysis.
“This could be particularly useful for cervical cancer screening in low- and middle-income countries with limited resources,” says Peter Sasieni.
Next steps in research
With support from the Swedish Cancer Society, we are conducting a large population study based on self-testing based on an alternative assay to test the feasibility of incorporating such risk stratification into routine screening programs. It is planned to be held in Sweden. We also want to investigate the predictive value of the current test results in combination with other markers for HPV-positive women.
This research was funded by Cancer Alliances, Cancer Research UK and the Swedish Research Council.
sauce:
Reference magazines:
Ray, J. others. (2024). Human papillomavirus genotype and cycle thresholds from self-samples and risk of high-grade cervical lesions: Post-hoc analysis of a modified step wedge implementation feasibility study. PLOS medicine. doi.org/10.1371/journal.pmed.1004494.
|
Sources 2/ https://www.news-medical.net/news/20241213/New-HPV-self-test-approach-could-enhance-cervical-cancer-screening.aspx The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: cgurgu@internetmarketingcompany.BizWebsite: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or collaboration@support.exbulletin.com
 |
 |
 |
