Health
Studies suggest that alpaca antibodies can prevent human coronavirus infections. Independent
The Swedish research team behind the new study could see that this neutralizing antibody, or’nanobody’, was developed as an antiviral treatment and could be used to combat a pandemic that has killed more than 800,000 people worldwide. I believe.
The search for effective Nanobodies that naturally occur in camelids and adapt to humans began in February when they were injected into Tyson, a 12-year-old alpaca. Coronavirus” Spike protein from scientists at the Karolinska Institute in Stockholm.
After 60 days, alpaca blood samples showed a strong immune response to spike proteins.
In June, the team reported that they separated a Nanobody from Tyson’s blood that could bind to the same part of the virus as a human antibody and block the infection.
The research team has now reported findings that it hopes to complete the study and ultimately lead to preclinical animal research before being used in the fight against the coronavirus.
“I hope our findings can contribute to the improvement of the Covid-19 pandemic by encouraging further testing of this Nanobody as a therapeutic candidate for this viral infection,” Tumor Cell Biology at the Karolinska Institute.
The team said that Nanobodies offer some advantages over traditional antibodies as candidates for specific treatments. They are less than one-tenth the size of traditional antibodies and are usually easy to manufacture in large scale and cost-effective ways.
“Critically, they are able to adapt to humans with current protocols and have a proven record of inhibiting viral respiratory infections,” the researchers said.
Leo Hanke, the first author of the study, said: “Using cryo-electron microscopy to see how Nanobodies bind to viral spikes with an epitope that overlaps with the cell receptor ACE2 binding site and a strong neutralizing activity.”
According to his colleague Ben Müller, an associate professor in the fields of microbiology, oncology and cell biology, and co-author of the study: [the nanobody] Ty1 binds strongly to the SARS-CoV-2 (formal name of the virus that causes Covid-19) spike protein and can neutralize the virus without detectable off-target activity.
“We are currently undertaking a preclinical animal study investigating the neutralizing activity of Ty1 in vivo and its therapeutic potential.”
The Swedish team is not the only investigator investigating the potential of Nanobodies from alpaca.
Researcher at the University of Kentucky School of Medicine We are also researching Nanobodies Produced by three alpaca, Big Boy, Blue Eyes, and Emperor.
The study is published in a journal Natural communication.
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