Health
Insulin genes hit evolutionary obstacles
Type 2 diabetes is a chronic health condition in which the body cannot use insulin hormones as expected.Your body develops Insulin resistance And it leads to high levels of sugar in your bloodstream. Also called adult-onset diabetes, middle-aged and older people can develop this condition. But now obesity And environmental factors, even children and adolescents, are becoming prey to this disease.
Insulin is an important hormone in the human body.The evolution of insulin in vertebrates, including humans, faces disorders, limiting their ability to adapt to obesity and thereby vulnerable to most people. Type 2 diabetes, An important study claims. Scientists at the University of Indiana (IU), the University of Michigan, and Case Western Reserve University have determined that insulin sequences are at the edge of production disorders. This is an inherent vulnerability revealed by a rare mutation in the insulin gene that causes diabetes in childhood.
The biological process behind this disorder
Insulin is produced by a series of highly specific processes that occur in specialized cells called Beta cells.. An important step is to fold a biosynthetic precursor called proinsulin to achieve the functional three-dimensional structure of the hormone. Previous studies have suggested that impaired biosynthesis may be the result of a variety of mutations that impede the folding of proinsulin. Biological processes usually evolve robustly, which in most cases protects us from birth defects and illnesses. Still, diabetes seems to be an exception.
Cell stress causes beta cell dysfunction
In this group, even the slightest changes in the insulin sequencing process impair insulin folding (and ultimate insulin secretion), as well as cellular stress leading to beta cell dysfunction and ultimately permanent damage. Was found to induce.Studies published in Minutes of the National Academy of SciencesEmphasizes the importance of folding efficiency as an important but hidden factor in the evolution of insulin over the last 540 million years.
Understanding the Cause of Type 2 Diabetes
Humans have evolved to be vulnerable to diversity mutation Being in the insulin gene, this vulnerability underlies a rare single genotype Diabetes And it provides an evolutionary background to the current obesity-related diabetes pandemic. The authors of this study emphasize the fact that insulin genes are evolutionarily susceptible to mutations that impair insulin function or stress beta cells. As we celebrate the 100th anniversary of the discovery of insulin, these sophisticated observations may lead to a better understanding of the etiology of type 2 diabetes. This group works to fully define the sequencing factors that make proinsulin foldable in beta cells.
Common Symptoms of Type 2 Diabetes
Symptoms of this condition can be very subtle and difficult to recognize. In most cases, your doctor may diagnose this condition when you go to a general health check for other illnesses. However, common signs of type 2 diabetes include unnatural thirst, frequent urination, blurred vision, and uneven mood. You may also experience tingling and numbness in your hands and feet, and general malaise. It may take longer for the wound to heal and you may be hungry more than usual.Sudden weight loss and frequent Infection The color of the skin on the neck and armpits may also change.
(With input from IANS)
Release date: November 7, 2020 17:12
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