Scripps Research Lab uses DNA sequencing to track coronavirus

San Diego Scientist Scripps Research La Jolla uses genomic sequencing to track the spread of the coronavirus in San Diego County. They do it by analyzing small changes in the virus as it travels from person to person.

The coronavirus, which infects more than 10 million people in the United States, is constantly changing, just like the influenza virus.

“Influenza has a high ability to evade the vaccine, which means that the vaccine needs to be updated each year to match the variants of the flu that are likely to hit us in the upcoming flu season. “I will,” said the doctor. Christian Andersen, Professor of Immunology, Scripps Research.

Dr. Andersen analyzes the coronavirus genome as the virus travels through different parts of the county.

For example, when testing people infected with COVID-19 in Tijuana, the virus may have a slightly different genome than the virus that infected people on the oceanside.

By tracking these small changes, Andersen can see where the virus is moving and identify superspreader events.

“I know how a virus is evolving in the absence of a vaccine. It’s like bouncing around in an evolutionary space. The problem is that when you introduce a vaccine, you’re seeing what you’re doing now. Is it starting to look different, “Andersen said.

Another question is, will the coronavirus become resistant to future vaccines like influenza? I don’t know yet, Andersen said. However, he is optimistic that scientists can continually update their vaccines as needed.

“Our ability to update vaccines based on this type of sequence is much easier than actually developing the first vaccine,” Andersen said.

In the meantime, we need to stay vigilant while waiting for the vaccine to hit the market.

“Wearing an effective face mask and being physically separated from others is a way to control this virus,” he said.

According to Andersen, 80% of coronavirus transmissions are responsible for superspreading events, and most commonly, the virus spreads by talking, coughing, and screaming, especially in indoor spaces. ..

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