Health
Potential drug treatment for deadly childhood cancer
Sydney, February 14 (IANS) Researchers have identified a potential new drug treatment for diffuse intrinsic bridge glioma (DIPG) in fatal childhood cancer.
Published in the journal Nature Communications, the study reveals a combination of drugs that may be “very effective in eradicating cancer cells” in animal studies and the world’s first 3D model of tumors.
In preclinical studies in mouse models, researchers found that promising drug combinations led to survival in two-thirds of mice, and drug combinations resulted in the growth of these highly aggressive tumors in these mice. I have found that it completely stops the mouse.
Importantly, drug therapy, which is currently in early trials for adult cancer, is the most effective treatment ever tested in this incurable childhood cancer laboratory model, Australia said. Researchers, including David Ziegler of the Children’s Cancer Institute, said.
Treatment is a combination of two well-established drugs, difluoromethylornithine (DFMO) and AMXT 1501. DFMO is gaining increasing attention as a treatment for difficult-to-control cancers such as neuroblastoma, another advanced childhood cancer, and colorectal cancer. As an adult. According to the team, DFMO works by targeting the polyamine pathway. This is an important mechanism that enables the growth of tumor cells.
For this study, the team developed Australia’s first DIPG research program using tumor cells donated by parents of children who died of illness. From these, they created the first laboratory model of tumors to test new drugs. According to the team, these models are used to show that DIPG can avoid DFMO activity by delivering polyamines into the cancer, essentially demonstrating that tumors continue to grow despite treatment with DFMO. It is possible.
They are now making the breakthrough discovery that treatment with the newly developed drug AMXT 1501 strongly blocks the transport of polyamines to DIPG cancer cells.
Treatment with AMXT 1501 was found to resensitize DIPG cells to DFMO, and Ziegler said, “In animal models, a great response with significantly improved survival and minimal toxicity (side effects). It was. “
–IANS
vc / sdr /
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
Pictures Credit
to request, modification Contact us at Here or [email protected]
 |
 |
 |
