Health
Mavacamten may be a breakthrough treatment for hypertrophic cardiomyopathy
Use of mabacamten, a cardiac myosin inhibitor Symptomatic obstructive hypertrophic cardiomyopathy (HCM)According to the interim results of the EXPLORER-HCM prolongation trial, showed continuous and consistent benefits for quality of life and outcomes over the long term.
These latest findings are American College of Cardiology (ACC) 2022 Scientific Session in Washington, DC..
In MAVA-LTE, agents were associated with a significant improvement in the left ventricular outflow tract (LVOT) gradient, as well as improvements in both NT-pro BNP and NYHA classes.
In an interview with HCPLiveCedars-Sinai, Lead Author, Florian Rader, MD, Co-Director, Hypertrophic Cardiomyopathy and Aortology Clinic, emphasized the importance of more data on the new drug class of HCM.
“I think people were looking for longer-term safety data for this all-new drug class,” Rader said. “Fortunately, we found that there were no new safety signals or new concerns, and that there were some patients who dropped ejection fraction to less than 50% of the protocol-defined cutoff. All are reduced ejection fractions, all of which were reversible. “
He noted the importance of long-term prolongation in determining that long-term exposure to new drugs does not cause an increase in the incidence of low emissions.
“Overall, I think these results are very encouraging that this won’t happen,” Raider said. “But we follow those patients and make sure they’re doing well throughout the five-year follow-up period.”
Radar further expressed his thoughts on ensuring that Maba Kamten is a game changer for HCM patients and does not need to undergo invasive treatment.
“More than 60 years ago, since HCM was first described, there was really no specific targeted medication for the disease, and Mabacamten is now the most promising candidate for this role.”
Keeping in mind that it may be approved at the end of April, Rader discussed what the agent uptake would be.
“Like any other new drug class, I think a large HCM center that will probably adopt this new drug will be a little faster than a small clinic,” he said. “And it probably depends on how strict the safety monitoring requirements for this new drug are, and price can also play a role.”
“The latest cumulative results of treatment with mabacamten from the EXPLORER-LTE cohort of MAVA-LTE studies in patients with obstructive hypertrophic cardiomyopathy” was presented at ACC2022.
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