Health
Discovery of a toxin that kills bacteria could pave the way for a new generation of antibiotics
Researchers at McMaster University have discovered a previously unknown bacteria-killing toxin that could pave the way for a new generation of antibiotics.
Led by John Whitney of the Michael G. DeGroote Institute for Infectious Disease Research, the study suggests that bacterial pathogens Pseudomonas aeruginosaIt is known to cause nosocomial infections such as pneumonia.
For Whitney, that wasn’t the only important aspect of his discovery. This toxin kills bacteria, but how I will.
This study is important because it shows that the toxin targets essential RNA molecules in other bacteria and prevents them from functioning effectively. Like humans, bacteria need properly functioning RNA to survive. “
John Whitney, Associate Professor, Department of Biochemistry and Biomedical Sciences
“It’s a complete assault on the cell because of the large number of important pathways that depend on functional RNA,” says first study author Nathan Barren, a graduate student in McMaster’s Department of Biochemistry and Biomedicine. increase.
“This toxin penetrates its target, hijacks essential molecules necessary for life, and uses them to disrupt normal processes.”
Whitney and Bullen, along with colleagues at Imperial College London and the University of Manitoba, have been studying this toxin for almost three years to understand exactly how it works at the molecular level.
Breakthrough published in molecular cellachieved by Bullen after rigorous experiments on common targets for toxins, such as proteins and DNA molecules, before finally testing the toxin against RNA.
The findings break the established precedent set by toxins that target proteins secreted by other bacteria, such as the bacteria that cause cholera and diphtheria.
The researchers say the development has great potential for future research and could ultimately lead to new innovations in fighting infection-causing bacteria.
Whitney said the newly discovered vulnerability could be exploited for future antibiotic development.
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Journal reference:
Bren, NP, and others. (2022) ADP-ribosyltransferase toxins kill bacterial cells by modifying structured noncoding RNA. molecular cell. doi.org/10.1016/j.molcel.2022.08.015.
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