Two powerful drugs are stepping into the illicit drug supply

two dangerous and powerful illegal drugs increasingly penetrating the supply of street drugputting people at risk of a fatal overdose.

One is a class of synthetic opioids called Nitazen, which are up to 10 times more potent. Fentanylexperts say. Fentanyl It’s already 50 times more powerful than heroin.

Thursday, Tennessee Department of Health public data Over the past two years, there has been a four-fold increase in fatal overdoses associated with nitazen.

According to reports, no Nitazen-related deaths were reported in Tennessee in 2019. However, in 2020, 10 such deaths were reported. In 2021, that number has increased to 42.

“Nitazen is a new group of highly potent psychoactive substances,” the authors of the report wrote.

in the meantime naloxoneAlso Narkanis very effective in reversing an opioid overdose, but Tennessee health officials are concerned that nitazen is so potent that multiple doses of rescue medication may be required. increase.

The most powerful opioids are street drug Since 2019, it has spread to the Midwest and Northeast, but has since spread to other states.

“We held our breath and waited when we would see it,” said Erin Tracy, a research chemist at the University of North Carolina Center for Injury Prevention Research in Chapel Hill.

She and her colleagues recently began detecting Nitazen. illegal drug samples gathered from all over the country.

Tracy et al. also found traces of the non-opioid animal tranquilizer xylazine. Fentanyl sample.

“It’s a disaster in itself waiting to happen,” she said.

Xylazine is used for sedation Horses, dogs and other animals before veterinary surgery. Xylazine is not detected in typical toxicology tests.

Increasingly, however, animal sedatives are being found laced with illegal injectable drugs, often referred to as “tranq” or “tranq dope.” Those who use it tend to be unconscious for hours.

“This severe sedation puts people in a really dangerous place, making them vulnerable to sexual assault and robbery,” said Dr. Laura Kehoe, medical director of the Massachusetts General Hospital Substance Use Disorders Bridge Clinic. increase.

Xylazine’s sedative effects are so strong that lying face down on a pillow, for example, can cause suffocation, says Joseph Drazio, Ph.D., associate professor of clinical emergency medicine at Temple University’s Louis Katz School of Medicine. says. Philadelphia.

The drug has also been associated with reports of skin abscesses, unlike cases seen in other injectable drug users. cutting is required.

“There’s definitely an increase in the number of chronic wounds from drug injections,” D’Orazio said, adding that there’s no evidence that xylazine itself leads to these open wounds.

However, he and other experts believe that several factors may be involved in xylazine use. Drugs can reduce blood flow and reduce the body’s ability to heal. It also increases the likelihood that users will engage in skin picking, which can lead to open wounds.

“This is really a poison supply,” Kehoe said.

This story first appeared NBCNews.com.

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