Health
COVID vaccines and MS relapse risk: new data
Top line:
COVID-19 vaccination is not associated with an increased risk of multiple sclerosis (MS) relapse in most patients, although patients with active MS have a small increased risk of relapse after a COVID-19 booster vaccination.
Methodology:
- The researchers conducted an observational study using data from the French National Health Data System.
- As of January 1, 2021, 124,545 people with MS have been identified, of whom 82.3% have received at least one dose of a COVID-19 vaccine.
- The analysis included data after the first three doses of a COVID-19 vaccine.
- The primary outcome was MS relapse requiring hospitalization and treatment with high-dose corticosteroids within the 45-day risk period after each vaccination.
remove:
- No association was found with an increased risk of recurrence after the first or second dose of the COVID-19 vaccine, or after a booster dose.
- Subgroup analysis showed that in patients with two or more relapses in the previous two years, booster vaccination was associated with a 28% increased risk of relapse (incidence rate ratio, 1.28). P = .006), especially in treatment-naive patients.
- To confirm these findings, the researchers also conducted a case-control study and found no increased risk of recurrence after any of the three doses.
- The researchers found an association between vaccination and a reduced risk of recurrence (odds ratio, 0.90; P = .01).
Exercise:
“Our findings reassure us that these vaccines can be used without worrying about the risk of recurrence,” said senior author Xavier Moisset, MD, PhD, of the University of Clermont Auvergne in Clermont-Ferrand, France. press release“The absence of such risks is reassuring for people with MS, especially if they need to receive multiple booster shots in the future, as they will be able to receive booster shots when they need them,” he added.
sauce:
The study was led by Moisset et al. Publish online On August 14th Neurology.
Limitations:
The main limitations are that we relied on hospital care and drug reimbursement data that lacked clinical information, benign recurrences may have been under-reported, and pseudo-recurrences may have been misidentified as real recurrences.
Disclosure:
This study received no specific funding. Some authors declared financial and non-financial support from various pharmaceutical companies. Additional disclosures can be found in the original article. Full disclosures can be found in the original article.
This article was created using multiple editorial tools, including AI as part of the process; a human editor reviewed this content before publishing.
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Sources 2/ https://www.medscape.com/viewarticle/covid-vaccine-and-ms-relapse-risk-new-data-2024a1000ffg The mention sources can contact us to remove/changing this article |
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