Health
Anti-COVID-19 Nasal Spray “Ready to Use in Humans”
Credit: University of Birmingham
Nasal sprays that can provide effective protection against the COVID-19 virus were developed by researchers at the University of Birmingham using materials that are already approved for human use.
A team at the University’s Healthcare Technologies Institute prescribed sprays using compounds that have already been widely approved by UK, European, and US regulators.Materials are already widely used in medical devices, pharmaceuticals and even more widely Food..
This means that the usual complex steps to bring a new product to market are greatly simplified, and sprays can be marketed very quickly.
Preprinted (not yet peer-reviewed) studies describe cell culture experiments designed to test the ability of solutions to inhibit infection. They found that cell virus cultures inhibited infection up to 48 hours after being treated with solution and when diluted multiple times.
The spray is composed of two polysaccharide polymers. The first, an antiviral agent called carrageenan, was commonly used in foods as a thickener, and the second solution was chosen because of its ability to attach to cells in the nose.
Gellan is an important component because of its ability to spray fine droplets inside. Nasal cavityWhere it can evenly cover the surface and stay at the delivery location instead of sliding down and out of the nose.
The lead author of the treatise, Dr. Richard Moke’s, said: “This spray is made from readily available products that are already in use in foods and medicines. We deliberately incorporate these conditions into the design process, our partners, within a few weeks. We were able to start mass production. “
The spray works in two main ways. First, it can catch and cover the virus inside the nose, from which it can be eliminated via the usual channels (blow or swallow). Second, the virus is encapsulated in a viscous coating of the spray, which prevents it from being taken up by the body.This not only reduces the viral load in the body, but also reduces the likelihood that the virus particles will be transmitted to another person through sneezing or coughing, but that person will be infected with something active. Virus particles..
Co-author Professor Liam Grover said: “Our nose filters thousands of liters of air each day, but there is little protection from infection, and most aerial viruses are transmitted through the nasal passages. The spray we prescribed provides that protection. However, it can also prevent the virus from being transmitted from person to person. “
The team finds sprays to be especially useful in areas where congestion is unavoidable, such as airplanes and classrooms. Regular application of the spray can significantly reduce the transmission of the disease.
“Such products do not replace existing measures that remain essential to prevent the spread of the virus, such as wearing masks and washing hands,” Dr. Mokes adds. “What is this injection However, it adds a second layer of protection for prevention and slowdown Virus Infection; infection. ”
Richard JA Moke’s et al. Prescription of compound nasal drops that enables enhanced surface coating and prevention of SARS-COV-2, (2020). DOI: 10.1101 / 2020.11.18.388645
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University of Birmingham
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