Health
Scientists decipher how coronavirus interacts with proteins in human cells
Scientists have illustrated the first atlas to show how the new coronavirus genetic material interacts with proteins in human cells. This could be a starting point for the development of new treatments for Covid-19.
One of the most urgent challenges, according to researchers, including researchers at the Broad Institute in the United States, is to understand all the molecular interactions between the virus and the cells it infects.
They explained that a detailed understanding of these interactions would help identify the processes in the host cell that favor the growth of the virus and the processes that activate the host’s immune system.
Although the SARS-CoV-2 virus replicates using host proteins, scientists have a detailed understanding of all proteins that occur in human cells that interact with RNA, the genetic material of the virus. Said not.
In a current study published in Nature Microbiology, scientists have created the first global atlas of direct interactions between SARS-CoV-2 RNA and proteins present in human cells.
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Based on the findings, researchers also identified key regulators of viral replication.
Scientists have infected human cells with a new coronavirus, purified viral RNA, and identified proteins that bind to it.
“In this particular case, we were able to make quantitative measurements to identify the strongest specific binding partners,” said Mathias Munschauer, research co-author of the Helmholtz RNA-Based Infection Research Institute (HIRI) in Germany. Stated.
Scientists have found that the RNA-protein interaction atlas provides unique insights into SARS-CoV-2 infection, allowing systematic degradation of factors that influence viral replication, and host defense strategies-new treatments. He said it provides important prerequisites for the development of the law.
From the results, scientists identified 18 host proteins that play important roles during SARS-CoV-2 infection and discovered 20 small molecules that could inhibit these proteins.
They believe that two proteins, CNBP and LARP1, are of particular interest.
Researchers have also identified target sites for these proteins that can be used to inhibit viral replication.
According to Munschauer, the characterization of LARP1 as an antiviral factor is a major finding.
“The way LARP1 binds to viral RNA is very interesting because it is similar to the way LARP1 regulates certain cellular messenger RNAs that we already know. This gives us insight into possible mechanisms of action. You can, “he added.
According to scientists, three of the four small molecules they tested inhibited viral replication in a variety of human cell types. This is a discovery that may open up new ways to treat Covid-19.
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