University of Alberta Spin-Off Company Searches for Antiviral Compounds to Treat COVID-19

48 Hour Discovery, a U of A spin-off company founded three years ago by chemist Ratmil Derda (pictured), uses proprietary technology to find promising potential compounds for COVID-19. Sifting billions of molecules. (Photo: John Ulan)

University of Alberta spin-off companies are adding state-of-the-art technology to the search for antiviral compounds to treat people infected with COVID-19.

Founded by chemist U Ratmil Derda In 2017 48 hours of discoveryTechnology applies the power of big data to the world of molecular discovery by allowing scientists to screen billions of molecules at once, rather than testing potential compounds individually. To do.

“Our proprietary technology allows for a much faster discovery process, bringing promising molecules to the clinic faster than ever before,” he explained. John Dwyer, Vice President of Research at 48Hour Discovery. “We are searching a billion peptide library for compounds that can be optimized as antiviral agents against COVID-19.”

Currently, there is no effective cure for prevention or treatment COVID-19 infection.

Recent studies have completed a novel coronavirus genomic sequence. 48HourDiscovery scientists use this information in combination with company technology to screen and optimize potential drug candidates for treating people infected with COVID-19.

“Our top priority is to find potential partners after optimizing and initial testing prospective candidates before moving on to preclinical and clinical evaluation,” said a similar drug program during the 2003 SARS outbreak. Dwyer worked on explained.

“The goal is to have pre-clinical attractive compounds ready for preclinical trials by the end of 2020.”

We also work with external stakeholders and partners to provide access to the search platform and to support rapid discovery services for other projects related to COVID-19, such as test development and other treatment options. I will.

48Hour Discovery is currently investing its own resources to support COVID-19 research, but is looking for partners to accelerate development.

“48-hour Discovery has benefited greatly from its close relationship with the University of Alberta and the Faculty of Science,” Derda said. “Continuous support from the university and its infrastructure is important for COVID-19 related projects.”

/ University of Alberta released. View full text here.

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