Preliminary results were obtained from the RECOVERY trial, which has been testing potential Covid-19 treatments since March 2020. Tocilizumab was added to the trial in April 2020. Results have not yet been published in peer reviews or medical journals, but will be available in preprints.
In the study, 2,022 patients were randomly assigned to tocilizumab and compared to 2,094 patients who received standard treatment.
“People in the tocilizumab group died 596, 29%, and those in the normal care group died 694, 33%, which means that the risk of death was about one-sixth or one-seventh. “Decreases.” Martin Landley, a professor of medicine and epidemiology at the Nafield School of Population and Health at Oxford University and a deputy principal investigator in recovery trials, said in a briefing Thursday.
“Absolute difference of four-hundredths,” Randley said. “To save one patient, one life, we need to treat about 25 patients.”
Landray said the benefits were consistent across all groups of patients studied.
The drug was also beneficial to people who were not on ventilator at the start of the study and was shown to reduce the risk of developing ventilator or death from 38% to 33%. It was.
The benefits of this drug were seen in addition to the benefits of steroids such as dexamethasone. Eighty-two percent of patients were on one of these steroids.
“Data show that in Covid-19 patients with hypoxia (requiring oxygen) and severe inflammation, treatment with a combination of systemic corticosteroids (such as dexamethasone) and tocilizumab requires simple oxygen. It reduces patient mortality by about one-third and requires invasive mechanical ventilation, “said a press release from Oxford University.
February 3,
National Institute of Health The Panel has published treatment guidelines for patients in the intensive care unit, stating that “there are insufficient data to recommend or oppose the use of tocilizumab or sarilumab in the treatment of Covid-19.” Sarilumab is a similar treatment for rheumatoid arthritis. For those who do not require ICU-level care, the Panel did not recommend the use of drugs except in clinical trials.
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